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Nic Coltman

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Biography

Nic hails from Leicestershire, the famed-home of Stilton and Red Leicester Cheeses, the Melton Mowbray Pork pie, the Pukka Pie, and Walkers Crisps! He received his first degree from Sheffield Hallam University in Forensic Biosciences (B.Sc 1stClass Hons) with research into Anti-doping science/toxicology, developing analytical chemistry methodologies for the detection of WADA‘watch list’ compounds in human urine, under the supervision of Dr Tom Bassindale.

He received his first industrial appointment working for the CRO Huntingdon Life Sciences (now Envigo) in the department of analytical chemistry, in eco- and mammalian toxicology, with expertise built in GLP science, GC, LC and LC-MS/MS method development.

Nic then moved to the Universirty of Birmimgham (UoB) and read for a Master of Research degree in Molecular Mechanistic Toxicology (M.Res). He undertook his research with the pharmaceutical CRO Sygnature Discovery Ltd based in Nottingham, within the Department DMPK and Physical Sciences, developing novel assays to be used in pre-clinical Drug Discovery, under the supervision of Dr Timothy Schulz-Utermoehl. Following the successful research project, he was appointed as a scientist within the Department of Biology, working within client projects across several disease areas including Immunology and Inflammation and Oncology.

In September 2017, Nic re-joined UoB as an MIBTP iCASE student at the University of Birmingham under the supervision Dr Nikolas Hodgesand Dr Patricia Lalor. His work is centred around developing in vitromodels to reflect the human liver in vivo, with a particular focus on the mechanisms underpinning Drug Induced Liver Injury. His works is jointly funded by the BBSRC and Sygnature Discovery Ltd where Dr Timothy Schulz-Utermoehl is his industrial supervisor.

Nic undertook a three month mini-project (February – April 2018) with the MRC Toxicology Unit, in the laboratory of Professor Marion MacFarlane. His research there focussed on investigating the mitochondrial mechanisms of toxicity of troglitazone – a drug withdrawn from the market in 2001 for liver toxicity hazards.

Nic is an MIBTP student representative for the UoB programme. Since May 2018, Nic has been an ambassador for UoB’s Drug Discovery programme for the College of Life and Environmental Sciences, where he has helped organise their guest lecture series and raise awareness of Drug Discovery as a research discipline across its colleges.

Research Interests

Drug metabolism and toxicity, in sickness and in health. Mechanisms of molecular and genotoxicity toxicity. Development of in vitro models for use in pre-clinical drug discovery for predictive toxicology.

Presentations

Drug Metabolism Discussion Group Annual Meeting, September 2017, Cambridge, UK. Poster presentation and blitz talk: “An integrated panel of assays for the prediction of drug induced liver injury”

Drug Metabolism Group, Winter meeting 2017, London, UK. Poster presentation: “Development of a hepatic liability panel of assays to study drug-induced livery injury”

BBSRC MIBTP student symposium, September 2018, Warwick, UK. Poster Presentation:“The staged development of liver spheroids for toxicology and discovery DMPK”

Institute of Immunology and Immunotherapy symposium, November 2018, Birmingham, UK. Oral presentation: “Development of 3D culture systems to model liver disease”

Publications

In progress

Professional memberships

British Toxicology Society: member 2016 - present

Drug Metabolism Discussion Group (UK): member 2016 – present

Drug Metabolism Group (UK): member 2016 - present

The Drug Discovery Club (University of Birmingham, UK): 2018 – present

Beyond scientific research…

Outside of his research, Nic is an avid runner and enjoys the outdoors including hiking and rock climbing. If science ever fails him, Nic has spent the last 2 years renovating his home where he has learnt to plaster, brick-lay and undertake basic plumbing!