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Arzt, J; Branan, MA; Delgado, AH; Yadav, S; Moreno-Torres, KI; Tildesley, MJ; Stenfeldt, C (2019) Quantitative impacts of incubation phase transmission of foot-and-mouth disease virus. Scientific Reports. 9 10.1038/s41598-019-39029-0

Arzt, J; Branan, MA; Delgado, AH; Yadav, S; Moreno-Torres, KI; Tildesley, MJ; Stenfeldt, C (2019) Quantitative impacts of incubation phase transmission of foot-and-mouth disease virus. Scientific Reports. 9 10.1038/s41598-019-39029-0

The current investigation applied a Bayesian modeling approach to a unique experimental transmission study to estimate the occurrence of transmission of foot-and-mouth disease (FMD) during the incubation phase amongst group-housed pigs. The primary outcome was that transmission occurred approximately one day prior to development of visible signs of disease (posterior median 21 hours, 95% CI: 1.1-45.0). Updated disease state durations were incorporated into a simulation model to examine the importance of addressing preclinical transmission in the face of robust response measures. Simulation of FMD outbreaks in the US pig production sector demonstrated that including a preclinical infectious period of one day would result in a 40% increase in the median number of farms affected (166 additional farms and 664,912 pigs euthanized) compared to the scenario of no preclinical transmission, assuming suboptimal outbreak response. These findings emphasize the importance of considering transmission of FMD during the incubation phase in modeling and response planning.

Thu 14 Mar 2019, 07:58