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Hopkins, T; Goncalves, R; Mamani, J; Courtenay, O; Bern, C (2019) Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study. Int. J. Inf. Dis. 86 175-177.

Hopkins, T; Goncalves, R; Mamani, J; Courtenay, O; Bern, C (2019) Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study. Int. J. Inf. Dis. 86 175-177.

Background: Screening for Trypanosoma cruzi infection was performed amongst children in a rural community in the Bolivian Chaco, an area known for high prevalence. The force of infection (FOI) was estimated. Methods: A total of 423 children attending the local school were screened using the Chagas Detect Plus (CDP) rapid test (InBios International, Inc.). CDP-positive specimens were further tested by indirect haemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA. A catalytic model was used to estimate FOI. Results: Confirmed seroprevalence was 0.22, rising steeply with age. The mean age of seropositive individuals was 13 years. The calculated specificity of the rapid test was 91.9%. The annual incidence estimated from the FOI was 0.021. Conclusions: This study demonstrates persistent transmission and continuing high levels of T. cruzi infection in the Bolivian Chaco, and highlights the practicality of school-based screening.

Fri 27 Sep 2019, 09:22