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Levi Lab

What is chronotherapy?

We have clocks within our cells that govern the metabolism of drugs. So some drugs are best given at night and others during the day. Watch this short film to find out more.

What are circadian rhythmns?

Discover more about the biological processes we're researching and why learning more about our body clocks and tapping into this knowledge could improve health outcomes.

Recent publications and media coverage

  • Chemotherapy could work twice as well if given at the right time

  • Dallmann R, Okayr A, Levi F: Dosing Time makes the Poison: Circadian Regulation of Pharmacotherapy . Trends inmol Med 2016, 22 (5): 430-445.
  • Lévi F.A., Boige V.; Hebbar M.; Smith D.; Lepère C.; Focan C.; Karaboué A.; Guimbaud R.; Carvalho C.; Tumolo S.; Innominato P.; Ajavon Y.; Truant S.; Castaing D.; De Baere T.; Kunstlinger F.; Bouchahda M.; Afshar M., Rougier

See the Levi Lab's published work and media coverage.

Research Projects

Through our research we have found chronotherapy is reducing the toxicity of treatments and improving the quality of life of patients because it respects the circadian rhythms of the patients.

We perform molecular, physiological, pharmacology, mathematical, statistical, translational and clinical research, and contribute to the development of new technologies. Toward these goals, our research encompasses the use of in vitro, in vivo and mathematical models as well as big data and clinical trials.

Find out more about our work


A multi disciplinary team

groupThe Levi Lab's founding staff members include Professor Francis Levi (medical oncology), Dr Robert Dallmann (Assistant Professor, molecular chronobiology), Dr Pasquale Innominato (Associate Professor, medical oncology) and Dr Annabelle Ballesta (Assistnt Professor, systems biology).

Professor David Rand (WSB Director, mathematics), Dr Barbel Finkenstadt (Reader), Dr Julia Brettschneider (Associate Professor) and Dr Qi Huang (Warwick Statistics), Denise Vlachou, Kristin Abrahams and Beniamino Hadj-Amar (PhD students), and Helena Monje-Xandri (technician) are also part of the team.

We also work closely with the Chemistry Department at Warwick (Professor Peter Sadler, Professor Sebastien Perrier), and we are part of the Cancer Research Centre directed by Professor Nicholas James.

Meet our team.