9 April 2014, 12pm-1pm, Room GLT3, Warwick Medical School Building, University of Warwick
'Group A Streptococcus: invader and evader'
Professor Shiranee Sriskandan, Professor of Infectious Diseases, Department of Medicine, Faculty of Medicine, Imperial College London
Streptococcus pyogenes is a lethal human pathogen that causes both invasive disease as well as waves of tonsillitis and scarlet fever; indeed, the UK is currently experiencing an unprecedented surge in scarlet fever notifications. The bacterium elaborates a range of virulence factors including superantigens and the chemokine cleaving protease SpyCEP that underlie the severe disease phenotypes of severe toxic shock and necrotising fasciitis, yet little is known of the factors that allow the bacterium to spread within the human population.
Shiranee Sriskandan is Professor of Infectious Diseases at Imperial College London and Consultant in I.D. at Hammersmith Hospital. She trained at Cambridge University and London, undertaking MRC and GSK clinical fellowships after completing training in infectious diseases. Her clinical and research interests centre on the pathophysiology and management of severe Gram positive bacterial sepsis; group A streptococcal pathogenesis is a particular focus of her research group.