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Stephen Renshaw

Wednesday 28th September 2016 - Zebrafish models of infection and inflamation.

Disordered immunity can lead to predisposition to infection or to inflammatory tissue damage. Tight control of immune processes must be balanced against the need to rapidly activate immunity in the presence of invading microorganisms. Our understanding of the regulation of innate immunity and host-pathogen interaction is aided by new models of immunity in which every innate immune cell can be seen throughout infectious or injurious challenge and in which genetic manipulations can be readily made.

Our laboratory has pioneered the zebrafish as a model of immunity and used it to aid understanding of inflammation resolution and host immunity to staphylococcal infection. This talk will showcase the model and how it can be used to investigate innate immune function in vivo, using examples from emerging research in the lab.


Steve Renshaw is the Sir Arthur Hall Chair of Medicine at the University of Sheffield. He has been with the University of Sheffield since 1998. He studied medical sciences at Cambridge before moving to Oxford, where he qualified in clinical medicine in 1994. After a clinical rotation in Nottingham, he moved to Sheffield to take up a Wellcome Trust Clinical Training Fellowship, to work on the role of death receptor signalling in the regulation of neutrophil lifespan in inflammation with Professor Moira Whyte.

He was awarded his PhD in 2001, and became Clinical Lecturer in Respiratory Medicine. In 2004 he was awarded an MRC Clinician Scientist Fellowship, to develop a zebrafish model of inflammation and was appointed honorary consultant. In 2008 he was awarded an MRC Senior Clinical Fellowship to continue these studies and he has held an MRC Programme Grant since 2014.