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Epidemiological studies on the relationship between sleep and CVD

Paper: Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies European Heart Journal 32, 1484-1492 (2011) by Cappuccio, F. P. Cooper, D. D'Elia, L. Strazzullo, P. Miller, M. A. View article on PubMed 

The relationship between sleep duration and cardiovascular outcomes is made considerably clearer through this meta-analysis study conducted through collaboration between Professor F.P. Cappuccio and Dr M. Miller. They conducted a meta-analysis of data contained in prospective studies that had been prospective with follow-up >3 years, had duration of sleep at baseline, and reported incident cases of CHD, stroke, or CVD.

Overall, 15 studies (24 cohort samples) included 474 684 male and female participants with follow-up periods ranging from 6.9 to 25 years. They found that there was a biphasic relationship between sleep duration and morbidity.

Both short and long duration of sleep was associated with a greater risk of developing or dying of coronary heart disease, whereas long duration of sleep was also associated with a greater risk of CHD and stroke, and therefore that disturbances of normal sleeping patterns are predictors, or markers, of cardiovascular outcomes. The outcome of this analysis was featured in The Independent.