About the project
What is the PRiDE study about?
The aim of the PRiDE study is to assess whether low vitamin B12 levels during early pregnancy predicts the development of gestational diabetes mellitus (GDM). In addition, the study will look at certain differences between mothers who develop GDM and those who do not, namely dietary habits, socio-economic status, ethnic variations and the psychological impact the diagnosis.
The women will be closely followed up for the duration of their pregnancy and outcomes of babies born to these mothers will also be monitored. We hope that the findings of this study will help to better identify a mothers’ risk of developing GDM and improve outcomes for them and their babies.
Why is the PRiDE study unique?
This is the first study to be done in the UK to test whether certain vitamin levels in early pregnancy (eg. vitamin B12 and folate) are related to the development of GDM. It is also unique because we will be comparing pregnancy outcomes on mothers of White Caucasian and ethnic minority origin (eg. South Asians). We hope this may answer questions about why some mothers are at higher risk of GDM and what implications this has for them and their babies.
Who can take part?
You can join this study if you are in the early stages of your pregnancy (before 16 weeks) and between the ages of 18 and 45. You should also be in the category of mothers who will be offered a glucose test for detecting GDM (you midwife or GP will be able to tell you more about this test and if you should have it)
Why should I take part?
Taking part in this study will help you and other pregnant mothers in the future to know more about their risk of GDM and the impact it could have on their babies.
What will happen if I choose to take part in the study?
You and your baby will be provided exactly the same care during your pregnancy whether you choose to participate or not. There is no additional intervention or treatment involved in the study.
If you decide to participate, we will need to take 2 additional blood samples from you during pregnancy (at the same time as your routine blood tests) and during the time of delivery. You will also be asked to provide urine and stool samples and fill out some questionnaires.
How long will I be in the study?
You will be in the study for approximately 9 months – from when you join (which will be around the time of your booking visit) until 6 weeks after delivery.