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Physiology, Disease and Therapeutics

The Maillard Reaction in biomedical research

 

Disease mechanisms and therapeutics

 

Historical perspective

 

Physiological formation and processing of glycation adducts

  • Glycation of proteins - fructosamines, AGEs and ALEs
  • Glycation of nucleotides
  • Glycation of basic phospholipids
  • Enzymatic defences against glycation
  • Genetic susceptibility to glycation - evidence frm twin studies

 

Glycation in disease

  • Kidney failure and dialysis
  • Cardiovascular and cerebrovascular disease
  • Alzheimer's disease and other neurological disorders
  • Liver cirrhosis
  • Arthritis and inflammatory disease
  • Other diseases

 

 


 

Drug design, development and therapeutics

 

Overview

 

Inhibition of glycation as primary pharmacological activity

  • Aminoguanidine (Pimagedine)
  • Thiazolium derivatives "AGE breakers"
  • Pyridoxamine
  • Thiamine and Benfotiamine
  • Carnosine
  • Other glycation inhibitors

 

Inhibition of glycation as secondary pharmacological activity

  • Metformin
  • Angiotensin converting enzyme (ACE) inhibitors
  • Other therapeutics with anti-glycation activity

 

 

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