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Sleep Research

Sleep Medicine and Epidemiology

Professor Cappuccio leads the group in the study programme on Sleep, Health & Society. The group is studying several aspects implicating short duration of sleep and ensuing increased daytime sleepiness, as a risk factor for cardiovascular risk factors, ill-health and other detrimental health effects. The group is studying the relationships between short duration of sleep and obesity, hypertension, diabetes and mortality in several population studies in children and adults, both cross-sectionally and prospectively. The socio-economic, hormonal and biochemical mechanisms possibly mediating some of these effects are also being explored. Furthermore, the group is involved in a study looking at the implications of implementing the European Working Time Directives (EWTD) of junior doctors in the UK and the changes in patient safety, doctors' fatigue, quality of life and effectiveness with reduced working hours and suitable rotas.

The following presentations on this subject have been made:


  • Royal College of Physicians Sleep Meeting (London)
  • British Sleep Society (Cambridge)
  • NHS Workforce Countdown (London)
  • Annual Meeting of the British Hypertension Society (Cambridge)
  • ThinkTank Museum (Birmingham)


  • World Association of Sleep Medicine (Bangkok)
  • American Heart Association Council on Epidemiology & Prevention (Orlando)
  • 21st Annual Meeting of the Associated Professional Sleep Societies (Minneapolis)
  • 22nd Scientific Meeting of the International Society of Hypertension (Berlin)
  • 19th Congress of the European Sleep Research Society (Glasgow)



  • Cappuccio FP, Cooper D, D’Elia L, Strazzullo P & Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 2011; 32: 1484-92
  • Cappuccio FP, Miller MA. Is prolonged lack of sleep associated with obesity? Br Med J 2011; 342: d3306
  • Cappuccio FP, Miller MA, Lockley SW. Sleep, Health & Society: from aetiology to public health. Oxford University Press, 2010; pp. 1-471
  • Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33(5): 585-92
  • Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Quantity and quality of sleep and incidence of type-2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2010; 33: 414-20
  • Cappuccio FP. 'Hospital at Night' improves outcomes: does the evidence support opinions? (Commentary) Q J Med 2009; 102: 583-4
  • Cappuccio FP, Lockley SW & Landrigan CP. Cappuccio response to correspondence (letter). Q J Med 2009; 102: 363-4
  • Cappuccio FP, Bakewell A, Taggart FM, Ward G, Ji C, Sullivan JP, Edmunds M, Pounder R, Landrigan CP, Lockley SW & Peile E on behalf of the Warwick EWTD Working Group. Implementing a 48h EWTD-compliant rota for junior doctors in the UK does not compromise patients' safety: assessor-blind pilot comparison. Q J Med 2009; 102: 271-82
  • Cappuccio FP, Lockley SW & Landrigan CP. EWTD is to improve health and safety of patients and doctors. Br Med J 2008; 337: a3080
  • Cappuccio FP & Lockley SW. Safety and the flying doctor. Br Med J 2008; 336: 218
  • Cappuccio FP, Taggart FM, Kandala N-B, Currie A, Peile E, Stranges S & Miller MA. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31(5): 619-26
  • Cappuccio FP & Stranges S. Response to: Gender-specific associations of short sleep duration with prevalent hypertension. Hypertension 2008; 51:e17
  • Cappuccio FP, Stranges S, Kandala N-B, Miller MA, Taggart FM, Kumari M, Ferrie JE, Shipley MJ, Brunner EJ & Marmot MG. Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. Hypertension; 2007: 50: 694-701
  • Currie A & Cappuccio FP. Sleep in children and adolescents: a worrying scenario. Nutr Metab Cardiovasc Dis 2007; 17: 230-2
  • Ferrie JE, Shipley MJ, Cappuccio FP, Brunner E, Miller MA, Kumari M & Marmot MG. Sleep duration and change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep 2007; 30: 1659-66
  • Miller MA & Cappuccio FP. Inflammation, sleep, obesity and cardiovascular disease. Curr Vasc Pharm 2007; 5
  • Miller MA, Kandala N-B, Kivimaki M, Kumari M, Brunner EJ, Lowe GDO, Marmot MG & Cappuccio FP. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep 2009; 32(7): 857-64
  • Miller MA, Kandala N-B, Kumari M, Marmot MG & Cappuccio FP. Relationships between sleep duration and von Willebrand factor, factor VII and fibrinogen: Whitehall II study. Arterioscler Thromb Vasc Biol 2010; 30: 2032-8
  • Miller MA & Cappuccio FP. Sleep and obesity. In: Obesity: Epidemiology, Pathophysiology and Prevention. CRC Press/Taylor & Francis, 2nd Edition, 2011, in press
  • Miller MA, Ahuja M & Cappuccio FP. Sleep and pregnancy: sleep deprivation, sleep disturbed breathing and sleep disorders in pregnancy. 2011, in press
  • Stranges S, Dorn JM, Cappuccio FP, Donahue RP, Rafalson LB, Hovey KM, Freudenheim JL, Kandala N-B, Miller MA & Trevisan M. A population-based study of reduced sleep duration and hypertension: the strongest association may be in pre-menopausal women. J Hypertens 2010; 28(5): 896-902
  • Stranges S, Cappuccio FP, Kandala N-B, Miller MA, Taggart FM, Kumari M, Ferrie JE, Shipley MJ, Brunner E & Marmot MG. Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II Study. Am J Epidemiol 2008; 167: 321-9
  • Stranges S, Dorn JM, Shipley MJ, Kandala N-B, Trevisan M, Miller MA, Donahue RP, Hovey KM, Ferrie JE, Marmot MG & Cappuccio FP. Correlates of short and long sleep duration: cross-cultural comparison between UK and US. The Whitehall II Study and the Western New York Health Study. Am J Epidemiol 2008; 168: 1353-64