I have been a Principal Research Fellow in Microbial Genomics at the University of Warwick at Warwick Medical School since April 2013. My primary interest lies in the exploitation of cutting edge high-throughput technologies in helping us elucidate mechanisms of bacterial pathogenesis such as motility. More recently, my studies have focused on clinical epidemiological studies within a hospital setting using high-throughput sequencing technologies.
I completed my undergraduate studies at Carnegie Mellon University in Pittsburgh USA. In 1989 I moved to the University of Birmingham where I did my PhD with Prof. Harry Smith and Prof. Jeff Cole on the mechanisms of serum induced resistance in Neisseria gonorrhoea. My interest in bacterial pathogenesis continued through a long collaboration with Prof. Charles Penn at Birmingham working on flagella regulation in Campylobacter jejuni and Helicobacter pylori and then using microarrays to study E. coli O157 and other E. coli strains. I have subsequently worked with Prof. Mark Pallen in establishing high-throughput sequencing capability at the University of Birmingham and carrying out clinical epidemiological studies in collaboration with Queen Elizabeth University Hospital Birmingham using instruments such as the Roche 454 Sequencer, Life Technologies PGM Ion Torrent and Illumina MiSeq. In 2013 I moved to Warwick Medical School as a Principal Research Fellow in Microbial Genomics.
- Magee, Eimear, Xie, Fengwei, Farris, Stefano, Dsouza, Andrea, Constantinidou, Chrystala, Zak, Alla, Tenne, Reshef, McNally, Tony, 2023. Polyelectrolyte complexation of chitosan and WS2 nanotubes. Advanced Materials Interfaces, 11 (6)
- 'Tupi?a, Dagnija, 'Krah, Alexander, 'Marzinek, Jan K., 'Zuzic, Lorena, 'Moverley, Adam A., 'Constantinidou, Chrystala, 'Bond, Peter J., 2022. 'Bridging the N-terminal and middle domains in FliG of the flagellar rotor. Current Research in Structural Biology, 4, pp. 59-67
- Stefanini, Irene, Stoakes, Emily, Wu, Houdini H. T., Xu-McCrae, Li, Hussain, Abid, Moat, John, Dowson, Christopher G., David, Miruna D., Constantinidou, Chrystala, 2022. Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility. Microbiology Spectrum, 10 (6)
- Li, Stephen, Lam, Jenna, Souliotis, Leonidas, Alam, Mohammad Tauqeer, Constantinidou, Chrystala, 2022. Posttranscriptional regulation in response to different environmental stresses in Campylobacter jejuni. Microbiology Spectrum, 10 (3)
- Grigonyte, Aurelija, Harrison, Christian, Macdonald, Paul R., Montero-Blay, Ariadna, Tridgett, Matthew, Duncan, John, Sagona, Antonia P., Constantinidou, Chrystala, Jaramillo, Alfonso, Millard, Andrew D., 2020. Comparison of CRISPR and marker-based methods for the engineering of Phage T7. Viruses, 12 (2)
- Unnikrishnan, Meera, Constantinidou, Chrystala, Palmer, Tracy, Pallen, Mark J., 2017. The enigmatic Esx proteins : looking beyond mycobacteria. Trends in Microbiology, 25 (3), pp. 192-204
- Millard, Andrew D., Westblade, Lars, LiPuma, John J., Vavikolanu, Kranthi, Read, Timothy, Pallen, Mark J., Burd, Eileen, Constantinidou, Chrystala, 2015. Genome Sequence of the Pandoraea apista LMG 16407 Type Strain. Journal of Bacteriology, 3 (6), pp. e01300-e01315
- Sergeant, Martin J., Constantinidou, Chrystala, Cogan, Tristan A., Bedford, Michael R., Penn, Charles W., Pallen, Mark J., 2014. Extensive microbial and functional diversity within the chicken cecal microbiome. PLoS ONE, 9 (3)
- Quick, Joshua, Constantinidou, Chrystala, Pallen, Mark J., Oppenheim, Beryl, Loman, Nicholas J., 2014. Draft genome sequence of Elizabethkingia meningoseptica isolated from a traumatic wound. Genome Announcements, 2 (3)
- Quick, Joshua, Cumley, Nicola, Wearn, Christopher M., Niebel, Marc, Constantinidou, Chrystala, Thomas, Christopher M., Pallen, Mark J., Moiemen, Naiem S., Bamford, Amy, Oppenheim, Beryl, Loman, Nicholas J., 2014. Seeking the source of Pseudomonas aeruginosa infections in a recently opened hospital : an observational study using whole-genome sequencing. BMJ Open, 4 (11)
- Bingle, Lewis E. H., Constantinidou, Chrystala, Shaw, Robert K., Islam, Md. Shahidul, Patel, Mala, Snyder, Lori A. S., Lee, David J., Penn, C. W., Busby, Stephen J. W., Pallen, Mark J., 2014. Microarray analysis of the ler regulon in enteropathogenic and enterohaemorrhagic escherichia coli strains. PLoS One, 9 (1)
- Halachev, Mihail R., Chan, Jacqueline, Constantinidou, Chrystala, Cumley, Nicola, Bradley, Craig, Smith-Banks, Matthew, Oppenheim, Beryl, Pallen, Mark J., 2014. Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumannii in Birmingham, England. Genome Medicine, 6 (11), pp. 1-13
- Remuiñán, Modesto J., Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J., Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Minick, Douglas J., Cacho, Mónica, Rebollo-López, María José, González, Carolina et al (Select to open full list), 2013. Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6',7'-Dihydrospiro[Piperidine-4,4'-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One, 8 (4)
- Gladstone, Rebecca A., Loman, Nicholas J., Constantinidou, Chrystala, Tocheva, Anna S., Jefferies, Johanna M. C., Faust, Saul N., O'Connor, Leigh, Chan, Jacqueline, Pallen, Mark J., Clarke, Stuart C., 2013. Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine. PLoS One, 8 (5)
- Loman, Nicholas J., Constantinidou, Chrystala, Christner, Martin, Rohde, Holger, Chan, Jacqueline, Quick, Joshua, Weir, Jacqueline C., Quince, Christopher, Smith, Geoffrey, Betley, Jason R., Aepfelbacher, Martin, Pallen, Mark J., 2013. A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-Toxigenic Escherichia coli O104:H4. JAMA: The Journal of the American Medical Association, 309 (14), pp. 1502-1510
- Martin, K., Baddal, B., Mustafa, N., Perry, C., Underwood, A., Constantinidou, Chrystala, Loman, Nicholas J., Kenna, D. T., Turton, J. F., 2013. Clusters of genetically similar isolates of Pseudomonas aeruginosa from multiple hospitals in the UK. Journal of Medical Microbiology, 62 (7), pp. 988-1000
- Chan, Jacqueline, Halachev, Mihail R., Loman, Nicholas J., Constantinidou, Chrystala, Pallen, Mark J., 2012. Defining bacterial species in the genomic era : insights from the genus Acinetobacter. BMC Microbiology, 12 (1)
- Clark, G., Paszkiewicz, K., Hale, J., Weston, V., Constantinidou, Chrystala, Penn, C., Achtman, Mark, McNally, A., 2012. Genomic analysis uncovers a phenotypically diverse but genetically homogeneous Escherichia coli ST131 clone circulating in unrelated urinary tract infections. Journal of Antimicrobial Chemotherapy, 67 (4), pp. 868-877
- Loman, Nicholas J., Constantinidou, Chrystala, Chan, Jacqueline, Halachev, Mihail R., Sergeant, Martin J., Penn, Charles W., Robinson, Esther R., Pallen, Mark J., 2012. High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity. Nature Reviews Microbiology, 10 (9), pp. 599-606
- Kochar, M., Crosatti, M., Harrison, E. M., Rieck, B., Chan, J., Constantinidou, Chrystala, Pallen, Mark J., Ou, H.-Y., Rajakumar, Kumar, 2012. Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant acinetobacter baumannii strain. Antimicrobial Agents and Chemotherapy, volume 56 (4), pp. 1845-1853
- Abrahams, Katherine A., Cox, Jonathan A. G., Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Fernández, Raquel, Alemparte, Carlos, Remuiñán, Modesto J., Barros, David, Ballell, Lluis, Besra, Gurdyal S., 2012. Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB. PLoS One, 7 (12)
- Constantinidou, Chrystala, Sergeant, Martin J., Cogan, Tristan, Penn, Charles W., Pallen, Mark J., 2012. High-throughput sequencing of 16S rRNA gene amplicons : effects of extraction procedure, primer length and annealing temperature. PLoS One, 7 (5)
- Chan, Jacqueline, Pallen, Mark J., Oppenheim, Beryl, Constantinidou, Chrystala, 2012. Genome sequencing in clinical microbiology. Nature Biotechnology, 30 (11), pp. 1068-1071
- Loman, Nicholas J., Misra, Raju V., Dallman, Timothy J., Constantinidou, Chrystala, Gharbia, Saheer E., Wain, John, Pallen, Mark J., 2012. Performance comparison of benchtop high-throughput sequencing platforms. Nature Biotechnology, 30 (5), pp. 434-439
- Chan, Jacqueline, Pallen, Mark J., Oppenheim, Beryl, Constantinidou, Chrystala, 2012. Genome sequencing in clinical microbiology. Nature Biotechnology, 30 (11), pp. 1068-1071
- Li, G., Tivendale, K. A., Liu, P., Feng, Y., Wannemuehler, Y., Cai, W., Mangiamele, P., Johnson, T. J., Constantinidou, Chrystala, Penn, C. W., Nolan, L. K., 2011. Transcriptome analysis of avian pathogenic Escherichia coli O1 in chicken serum reveals adaptive responses to systemic infection. Infection and Immunity, 79 (5), pp. 1951-1960
- Clarke, D. J., Chaudhuri, R. R., Martin, H. M., Campbell, B. J., Rhodes, J. M., Constantinidou, Chrystala, Pallen, Mark J., Loman, Nicholas J., Cunningham, A. F., Browning, D. F., Henderson, I. R., 2011. Complete genome sequence of the Crohn's disease-associated adherent-invasive escherichia coliStrain HM605. Journal of Bacteriology, 193 (17)
- Zarrilli, R., Giannouli, M., Rocco, F., Loman, Nicholas J., Haines, A. S., Constantinidou, Chrystala, Pallen, Mark J., Triassi, M., Di Nocera, P. P., 2011. Genome sequences of three acinetobacter baumannii strains assigned to the multilocus sequence typing genotypes ST2, ST25, and ST78. Journal of Bacteriology, 193 (9), pp. 2359-2360
- Cariss, S. J. L., Constantinidou, Chrystala, Patel, M. D., Takebayashi, Y., Hobman, J. L., Penn, C. W., Avison, M. B., 2010. YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli. Journal of Bacteriology, 192 (13), pp. 3329-3336
- Bailey, A. M., Constantinidou, Chrystala, Ivens, Alasdair, Garvey, M. I., Webber, Mark A., Coldham, N., Hobman, J. L., Wain, J., Woodward, M. J., Piddock, Laura J. V., 2009. Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. Journal of Antimicrobial Chemotherapy, 64 (5), pp. 973-985
- Moen, Birgitte, Janbu, Astrid Oust, Langsrud, Solveig, Langsrud, Øyvind, Hobman, Jon L., Constantinidou, Chrystala, Kohler, Achim, Rudi, Knut, 2009. Global responses of Escherichia colito adverse conditions determined by microarrays and FT-IR spectroscopy. Canadian Journal of Microbiology, 55 (6), pp. 714-728
- Filenko, N., Spiro, S., Browning, D. F., Squire, D., Overton, T. W., Cole, J., Constantinidou, Chrystala, 2007. The NsrR regulon of escherichia coli K-12 includes genes encoding the hybrid cluster protein and the periplasmic, respiratory nitrite reductase. Journal of Bacteriology, 189 (12), pp. 4410-4417
- Roe, A. J., Tysall, L., Dransfield, T., Wang, D., Fraser-Pitt, D., Mahajan, A., Constantinidou, Chrystala, Inglis, N., Downing, A., Talbot, R., Smith, D. G. E., Gally, D. L., 2007. Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157 : H7. Microbiology, 153 (number 5), pp. 1350-1360
- Kamal, N., Dorrell, N., Jagannathan, A., Turner, S. M., Constantinidou, Chrystala, Studholme, David J., Marsden, G., Hinds, J., Laing, K. G., Wren, B. W., Penn, C. W., 2007. Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the 54-dependent regulon in Campylobacter jejuni. Microbiology, 153 (9), pp. 3099-3111
- Tree, Jai J., Ulett, Glenn C., Hobman, Jon L., Constantinidou, Chrystala, Brown, Nigel L., Kershaw, Christopher, Schembri, Mark A., Jennings, Michael P., McEwan, Alastair G., 2007. The multicopper oxidase (CueO) and cell aggregation in Escherichia coli. Environmental Microbiology, 9 (8), pp. 2110-2116
- Hobman, J. L., Patel, M. D., Hidalgo-Arroyo, G. A., Cariss, S. J. L., Avison, M. B., Penn, C. W., Constantinidou, Chrystala, 2007. Comparative genomic hybridization detects secondary chromosomal deletions in escherichia coli K-12 MG1655 mutants and highlights instability in the flhDC region. Journal of Bacteriology, 189 (24), pp. 8786-8792
- Low, Alison S., Holden, Nicola, Rosser, Tracy, Roe, Andrew J., Constantinidou, Chrystala, Hobman, Jon L., Smith, David G. E., Low, J. Christopher, Gally, David L., 2006. Analysis of fimbrial gene clusters and their expression in enterohaemorrhagic Escherichia coli O157:H7. Environmental Microbiology, 8 (6), pp. 1033-1047
- Griffiths, L., Overton, T.W., Patel, M.D., Hobman, J.L., Penn, C.W., Cole, J.A., Constantinidou, Chrystala, 2006. Microarray analysis of gene regulation by oxygen, nitrate, nitrite, FNR, NarL and NarP during anaerobic growth of Escherichia coli : new insights into microbial physiology. Biochemical Society Transactions, 34 (1), pp. 104-107
- Constantinidou, Chrystala, 2005. A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, narXL, and narQP as Escherichia coli K12 adapts from aerobic to anaerobic Growth. Journal of Biological Chemistry, 281 (8), pp. 4802-4815
- Kershaw, C. J., Brown, Nigel L., Constantinidou, Chrystala, Patel, Mala D., Hobman, Jon L., 2005. The expression profile of Escherichia coli K-12 in response to minimal, optimal and excess copper concentrations. Microbiology, 151 (4), pp. 1187-1198
- Parsons, Nicholas R., Ashton, Peter R., Constantinidou, Chrystala, Cole, Jeffrey A., Smith, Harry, 1993. Identification by mass spectrometry of CMP-NANA in diffusible material released from high Mr blood cell fractions that confers serum resistance on gonococci. Microbial Pathogenesis, 14 (4), pp. 329-335
- Quraishi, M. N., Sergeant, Martin J., Kay, Gemma L., Iqbal, Tariq, Constantinidou, Chrystala, Chan, Jacqueline, Trivedi, Palak J., Ferguson, James W., Adams, David H., Pallen, Mark J., Hirschfield, Gideon, 2014. Probing the microbiota in PSC : the gut adherent microbiota of PSC-IBD is distinct to that of IBD and controls. The 65th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2014, Nov 2014, Published in Hepatology, pp. 264A-267A
Title | Funder | Award start | Award end |
---|---|---|---|
BBSRC Bioinformatics and biological resources: 2021: A Phylogenomic Resource for the Plant Pathogen Community | BBSRC | 01 Jul 2022 | 30 Jun 2027 |
Unveiling post-transcriptional regulation by sRNAs in C. jejuni | Medical and Life Sciences Research Fund | 01 Jun 2019 | 30 Nov 2020 |
Dissecting Host Pathogen Interactions of Clostridium Difficile | Medical and Life Sciences Research Fund | 01 Jul 2018 | 31 Dec 2019 |
Noreen Murray Award: Understanding the function and dynamicsof bacterial non-coding RNAs | University of Warwick (Donation) | 01 Mar 2014 | 30 Jun 2015 |