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New company, CryoLogyx, is spun out from the Department
A new biotechnology company, CryoLogyx, has been spun-out from the department, supported from a grant from InnovateUK. Cryologyx will be led by Dr Tom Congdon (A UoW UG and PG alumus) and will exploit technology developed by the GibsonGroup. Cryologyx will use innovative macromolecular (polymeric) cryoprotectants to protect biological samples, including cells used in therapy, diagnostics and drug discovery.
Read the news story here and more details will be released soon.
The department of Chemistry expects to appoint around 60 funded and self-funded PhD and MSc students in the 2021/2022 academic year
GibsonGroup's Glycosylated nanoparticles for selective galectin targeting is ‘HOT’ article in Chemical Science
Glycans (aka sugars, carbohydrates) direct many recognition and signalling processes in biology. Multivalency (presentation of lots of copies) is crucial to overcome glycans intrinsic low affinity, hence materials (polymers, particles, surfaces) which display them are appealing probes of function, or as new diagnostics (e.g. see our work on COVID diagnostics). However, most studies use simple monosaccharides, which may not have selectivity or are only tested against plant proteins. In this work, we collaborated with teams from Bristol, York and Southampton - our collaborators developed a chemoenzymatic synthesis to obtainselectively fluorinated glycans based on lacto-N-biose. Fluorine is appealing as it is small, does no have significant effects on conformation, but can change hydrogen bonding patterns. These glycans were incorporated into our polymer-stabilised nanoparticle platform, and found to modulate the affinity towards 2 galectins -an important class of galactose-binding biomarkers. This work shows that unnatural glycan-functional nanoparticles could be deployed as biosensors.