The latest Orbital newsletter
Chemistry World Today highlights Shipman Group Research into 'Synthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one'
Peptide-mimetic metallohelices bind Alzheimer protein and extend life in an insect model
Scott, Fox and Gibson develop 'metallohelical antifreezes'
A collaboration between the Fox, Scott and Gibson groups has been published in the Journal of the American Chemical Society. The team were inspired by how small helical antifreeze proteins in Nature enable extreomophiles to survive low temperatures, where other species would not survive. Rather than using traditional peptide/protein chemistry, the team used self-assembled metallohelicates which have similar dimensions to a small alpha helix, and found some which were remarkably potent at stopping ice crystal growth ; a major technological challenge in applications from wind farms, to aircraft to cryopreservation. Modelling studies showed that the underlying activity could be linked the patches of hydrophobicity (water liking) and hydrophobicity (water hating).
Read the paper here