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James Coverdale

Research fellow and bio-inorganic chemist at the University of Warwick, investigating the importance of zinc and its speciation in extracellular media.


Antiproliferative / toxicity assay screening services now available

We are now able to offer our antiproliferative activity / toxicity assay screening services to external companies at competitive rates. More information can be found here.


News

First-of-its-Kind Metallo-Catalyst Drug Selectivity Kills Cancer Cells

University of Warwick cancer researchers using ants in fight

Coverdale Osmium Cancer Catalyst Selectivity Anticancer University of Warwick cancer researchers using ants in fight

Could stinging nettles help destroy cancer cells? New treatment can target disease



Recent publications

2018

  • J. P. C. Coverdale, S. Khazaipoul, S. Arya, A. J. Stewart, C. A. Blindauer, "Crosstalk between zinc and free fatty acids in plasma" Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018, Manuscript accepted
  • J. P. C. Coverdale, H. E. Bridgewater, J. I. Song, N. A. Smith, N. P. E. Barry, I. Bagley, P. J. Sadler, I. Romero-Canelón, "In vivo selectivity and localization of reactive oxygen species (ROS) induction by osmium anticancer complexes that circumvent platinum-resistance" Journal of Medicinal Chemistry, 2018, Manuscript accepted
  • J. P. C. Coverdale, K. G. H. Katundu, A. I. S. Sobczak, S. Arya, C. A. Blindauer, A. J. Stewart, "Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding" Prostaglandins, Leukotrienes and Essential Fatty Acids, 2018, 135, 147-157
  • F. Chen, I. Romero-Canelón, J. J. Soldevila-Barreda, J. I. Song, J. P. C. Coverdale, G. J. Clarkson, J. Kasparkova, A. Habtemariam, M. Wills, V. Brabec, P. J. Sadler, "Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-sandwich Organoruthenium Catalysts" Organometallics, 2018, 37 (10), 1555-1566
  • F. Chen, J. J. Soldevila-Barreda, I. Romero-Canelón, J. P. C. Coverdale, J. I. Song, G. J. Clarkson, J. Kasparkova, A. Habtemariam, V. Brabec, J. A. Wolny, V. Schunemann, P. J. Sadler, "Effect of sulfonamidoethylenediamine substituents in Ru(II) arene anticancer catalysts on transfer hdyrogenation of coenzyme NAD+ by formate" Dalton Transactions, 2018, 47, 7178-7189
  • J. P. C. Coverdale, I. Romero-Canelón, C. Sanchez-Cano, G. J. Clarkson, A. Habtemariam, M. Wills, P. J. Sadler, "Asymmetric transfer hydrogenation catalysts in cancer cells" Nature Chemistry, 2018, 10, 347–354

Dr James P C Coverdale Warwick

Dr James P C Coverdale MRSC
Research Fellow
B608, Department of Chemistry
University of Warwick, UK
CV4 7AL

Email: J.Coverdale@warwick.ac.uk