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Chemistry Gibson Group

High-Impact Publications

Here are some of our most important papers/reviews which have featured in high-impact journals or have been indicated as 'hot' or highly cited

Richards, S-J., Jones, MW, Hunaban, M., Haddleton, DM., Gibson, M.I., Angewandte Chemie. International Edition., 2012, DOI: 10.1002/anie.201202945. "Probing Bacterial Toxin Inhibition with Synthetic Glycopolymers Prepared by Tandem Post-Polymerization Modification: Role of Linker and Carbohydrate Density" link

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This papers describes the us of tanden post-polymerization modification to precisely control the separation of carbohydrate and backbone in glycopolymers. This seperatation allows the carbohydrates to better access the deep binding pocket of the cholera toxin (B-subunit) increasing inhibitory activity. Conversely, another lectin (PNA) showed no sensitivity to the length of the linker, indicating that this is a powerful method to improve glycan seletivity without the need for complex cabohydrate synthesis.


 

Jones, M.W., Strickland, R. A., Schumacher, F.F., Baker, J.A., Gibson, M.I., Haddleton, D.M., Journal of the American Chemical Society, 2012, Online, "Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation agents and pegylation agents" link

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This paper shows a novel method to conjugate synthetic polymers to Native proteins. Dibromomaleimide's were incorporated at polymer chain ends, which allows them to insert into native disulfide linkages without affecting the proteins secondary structure. This method is far more versatile then traditional non-specific functionalisation (e.g active esters) and removes the need for genetically-engineered proteins. This technology will be used to improve the pharmocokinetic profiles therapeutically relevant proteins in the near future.

 

Bercer, C. R., Gibson, M. I., Ilyas, R., Geng, J., Wallis, R., Mitchel, D. A., Haddleton, D. M., Journal of the American Chemical Society, 2010, 132, 15130–15132,, "High Affinity Glycopolymer Binding to Human DC-SIGN and Disruption of DC-SIGN Interactions with HIV Envelope Glycoprotein" link

This paper describes our initial findings that mannose-rich glycopolymers can inhibit the interactions between DC-SIGN and the viral capsid protein, GP120. This demonstrates that synthetic polymers might find applicaiton in the inhibition of HIV infection

 

Gibson, M.I., Paripovic, D., Klok, H.-A., Advanced Materials, 2010, 22, 4721-4725, "Size Dependant LCST Transitions of Polymer-Coated Gold Nanoparticles: Co-operative Aggregation and Surface Assembly" link

Here we designed and synthesised a range of 'smart' nanoparticles which can respond to changes in temperature. This change normally results in precipitation, but we demonstrated that it was possible to use temperature to guide the assembly of nanoparticles onto complemntary surfaces, in a fully reversible manner.

 

Gibson, M. I., Cameron, N.R., Angewandte Chemie International Edition, 2008, 47, 5160-5162. “Organogelation of Sheet-Helix Block Copolypeptides.” link

In this work we demonstrate, for the first time, that it is possible to combine the two most famous structures in protein science - the alpha-helix and beta-sheet in a single block copolypeptide using NCA polymerization. These peptides were capable of undergoing supramolecular self-organisation to form extended fibres giving them remarkable organogelation properties.

Gibson, M.I., Polymer Chemistry, 2010, 1, 1141-1152, "Slowing the Growth of Ice with Synthetic Macromolecules: Beyond Antifreeze(glyco) Proteins" link. Featured on the front cover of the Journal.

 

This is the first independant publication of the newly formed Gibson Group at the University of Warwick. It summarises developments and trends in the application of synthetic polymers as biomimetics of Antifreeze Proteins - This is a key area of the Gibson group's reserach and several major publications are in preparation

 

 

Spain, S. G., Gibson, M. I., Cameron, N. R., Journal of Polymer Science, Part A: Polymer Chemistry, 2007, 45, 2059-2072. “Recent Advances in the Synthesis of Well-Defined Glycopolymers”. link Featured on the front cover of this issue and was in the Top 10 most accessed articles on the journal website for over 2 years. Cited almost 100 times.

This review article summarise the synthetic routes to obtain glycopolymers - polymers with pendant carbohydrate chains. This was the first effort to collect together and compare post-polymerization routes to these materials, which is now a hot topic in Polymer Chemistry

 

 

Gauthier, M. A., Gibson, M. I., Klok, H.-A., Angewandte Chemie International Edition, 2009,48, 48 – 58, “Synthesis of Functional Polymers by Post-Polymerization Modification”. link Featured on the inside cover of this issue.

This review article collates together a full range of synthetic techniques which are suitable for post-polymerization modification. At the time of publication, it was the most complete review of the area, which included the so called 'click' reactions. This is now used as a point of references for researchers seeking to optimise these reactions in the search of new 'click' chemistries