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Gibson Group: Antonio Laezza

Biography

Antonio Laezza was born in Naples, Italy in 1987. In July 2013 he graduated with a 1st Class Honours in Chemical Sciences at the University of Naples Federico II and in March 2014, he started his PhD “Regioselective modifications of natural polysaccharides.” The project looked to regioselective chemical functionalization and O-glycosylations of natural polysaccharides, investigating then their biological functions.
In May 2016 Antonio joined Uhrin Group at the University of Edinburgh as a Visiting PhD student with a project on the evaluation of the interaction between semy-synthetic ligand and selectins through STD-NMR.
In January 2018 Antonio joined the Gibson Group as a Postdoc with a project entitled “Software-controlled chemoenzymatic approaches to new glycomaterials”.


Research Interests

Antonio is currently involved in software-controlled chemoenzymatic polymer synthesis and evaluation of their biological function after incorporation into nanostructures.


Publications

[6] Bedini, E.; Laezza, A.; Parrilli, M.; Iadonisi, A. Carbohydr.Polym. 2017, 174, 1224-1239 “A review of chemical methods for the selective sulfation and desulfation of polysaccharides”

[5] Laezza, A.; Casillo, A.; Cosconati A.; Biggs, C.I.; Fabozzi, A.; Paduano L.; Iadonisi, A.; Novellino, E.; Gibson, M.I.; Randazzo, A.; Corsaro, M.M.; Bedini, E. Biomacromolecules 2017, 18 (8), 2267-2276 “Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity”

[4] Laezza, A.; Iadonisi, A.; Pirozzi, A.V.A.; Diana, P.; De Rosa, M.; Schiraldi, C.; Parrilli, M.; Bedini, E. Chem. Eur. J. 2016, 22, 18215-18226 “A Modular Approach to a Library of Semi-Synthetic Fucosylated Chondroitin Sulfate Polysaccharides with Different Sulfation and Fucosylation Patterns”

[3] Bedini, E.; Laezza, A.; Iadonisi, A. Eur. J. Org. Chem. 2016, 18, 3018-3042 “Chemical Derivatization of Sulfated Glycosaminoglycans”

[2] Laezza, A.; Iadonisi, A. De Castro, C.; De Rosa, M.; Schiraldi, C.; Parrilli, M.; Bedini, E. Biomacromolecules 2015, 16, 2237-2245 “Chemical Fucosylation of a Polysaccharide: A Semisynthetic Access to Fucosylated Chondroitin Sulfate”

[1] Laezza, A.; De Castro, C.; Parrilli, M.; Bedini, E. Carbohydr. Polym. 2014, 112, 546-555 “Inter vs. intraglycosidic acetal linkages control sulfation pattern insemi-synthetic chondroitin sulfate”

Presentations

Oral Presentations:

• NapOsaka meeting, Naples, Italy (10/07/2017)
• 19th European Carbohydrate Symposium EUROCARB, Barcelona, Spain (02/07/2017 – 06/07/2017)
• 7th Baltic Meeting on Microbial Carbohydrates, Gustrow, Germany (25/09/2016 – 29/09/2016)
• 4th EPNOE International Polysaccharide Conference, Warsaw, Poland (19/10/2015 – 25/10/2015)

Poster Presentations:

• XIV Convegno-Scuola sulla Chimica dei Carboidrati, Pontignano, Italy (22/06/2014 – 25/06/2014)

Grants and Bursaries


Royal Society – CNR International Fellowship, University of Warwick (2018-2020)


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Education

University of Naples Federico II

MSc: Chemical Sciences, University of Naples Federico II (2010-2013)

PhD: Chemical Sciences, University of Naples Federico II (2014-2017)

Email: a.laezza@warwick.ac.uk

Lab: 1.05/1.07 (MAS)

Address: Department of Chemistry, University of Warwick, Coventry, CV4 7AL