Our comprehension of the ways in which ultraviolet (UV) radiation is processed by biologically relevant molecules has become an important aim of time-resolved spectroscopy. I use transient absorption spectroscopy to study biological molecules to address two questions:
- Why Nature has chosen a set of building blocks (amino acids) that have an apparent intrinsic stability under UV radiation (sunlight)?
- How we can develop photo-initiated prodrugs that are more powerful and have lesser side effects than the currently used medications?
Transient Absorption Spectroscopy
In the Stavros lab we have an ultrafast UV-pump/visible-probe spectroscopy setup that can measure the excited state visible absorption of a sample following excitation with UV light, with a time resolution of <100 fs (femtosecond = 10-15 s) at pump-probe delays up to a few nanoseconds. Details of the setup may be found here.
For an excellent explanation of the technique watch this!
Email: s dot e dot greenough at warwick dot ac dot uk
Y. Zhao , G. M. Roberts, S. E. Greenough, N. J. Farrer, M. J. Paterson, W. H. Powell, V. G. Stavros and P. J. Sadler, Angew. Chem. Int. Ed., 51, 2012, 11263
S. E. Greenough, M. D. Horbury, J. O. F. Thompson, G. M. Roberts, T. N. V. Karsili, B. Marchetti, D. Townsend and V. G. Stavros, Phys. Chem. Chem. Phys., 16, 2014, 16187
|S. E. Greenough, G. M. Roberts, N. A. Smith, M. D. Horbury, R. G. Mckinlay, J. M. Zurek, M. J. Paterson, P. J. Sadler and V. G. Stavros, Phys. Chem. Chem. Phys., 16, 2014, 19141|