Senior Research Fellow
Alexia obtained a BA (Hons) and MSci in Natural Sciences at the University of Cambridge and then completed her PhD in 2013 in the lab of Jose Vasquez-Boland at the University of Edinburgh. Her research focused on the virulence mechanisms of the bacterial pathogen Rhodococcus equi, studying the interaction between the host and the pathogen and working towards vaccine development. In 2014 she moved to the University of Warwick to work as a Research Fellow in Nick Waterfield’s group where she continued studying the basis of the evolution of pathogenesis in bacteria. Her research then shifted to the study of the mechanisms of action of natural and synthetic antimicrobial compounds as well as the use of bacterial systems for drug delivery. In 2019 she joined Prof Sébastien Perrier’s group to work on the biological applications of synthetic polymers with a focus on antimicrobial polymers.
A dot Hapeshi at warwick dot ac dot uk
02476 5 28571
I am a member of the following research groups at Warwick:
- Hapeshi, Alexia, Benarroch, Jonatan Mimon, Clarke, David James, Waterfield, Nicholas R., 2019. Iso-propyl stilbene : a life cycle signal?. Microbiology, 165 (5), pp. 516-526
F1000Prime recommended article.
- Chen, Lihong, Song, Nan, Liu, Bo, Zhang, Nan, Alikhan, Nabil-Fareed, Zhou, Zhemin, Zhou, Yanyan, Zhou, Siyu, Zheng, Dandan, Chen, Mingxing, Hapeshi, Alexia, Healey, Joseph R. J., Waterfield, Nicholas R., Yang, Jian, Yang, Guowei, 2019. Genome-wide identification and characterization of a superfamily of bacterial extracellular contractile injection systems. Cell Reports, 29 (2), pp. 511-521.e2
- Simpson, Daniel *., Hapeshi, Alexia*, Rogers, Nicola J.*, Brabec, Viktor, Clarkson, Guy J., Fox, David J., Hrabina, Ondrej, Kay, Gemma L., King, Andrew, Malina, Jaroslav, Millard, Andrew D., Moat, John, Roper, David I., Song, Hualong, Waterfield, Nicholas R., Scott, Peter, 2019. Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways. Chemical Science, 10, pp. 9708-9720
Part of 2019 Chemicah Science HOT Article Collection
- Hapeshi, Alexia, Waterfield, Nicholas R., 2016. Photorhabdus asymbiotica as an insect and human pathogen. Current Topics in Microbiology and Immunology
- Valero-Rello, Ana, Hapeshi, Alexia, Anastasi, Elisa, Alvarez, S., Scortti, Mariela M., Meijer, Wim G., MacArthur, Iain, Vázquez-Boland, José A., 2015. An invertron-like linear plasmid mediates intracellular survival and virulence in bovine isolates of Rhodococcus equi. Infection and Immunity, 83 (3), pp. 2725-2737
- Mulley, Geraldine, Beeton, Michael L., Wilkinson, Paul, Vlisidou, Isabella, Ockendon-Powell, Nina, Hapeshi, Alexia, Tobias, Nick J., Nollmann, Friederike I., Bode, Helge B., van den Elsen, Jean, ffrench-Constant, Richard H., Waterfield, Nicholas R., 2015. From insect to man : photorhabdus sheds light on the emergence of human pathogenicity. PLoS One, 10 (12)
- Gonzalez-Iglesias, P., Scortti, Mariela M., MacArthur, Iain, Hapeshi, Alexia, Rodríguez, Héctor, Prescott, John F., Vázquez-Boland, José A., 2014. Mouse lung infection model to assess rhodococcus equi virulence and vaccine protection. Veterinary Microbiology, 172 (1-2), pp. 256-264
- Vázquez-Boland, José A., Giguère, Steeve, Hapeshi, Alexia, MacArthur, Iain, Anastasi, Elisa, Valero-Rello, Ana, 2013. Rhodococcus equi : the many facets of a pathogenic actinomycete. Veterinary Microbiology, 167 (1-2), pp. 9-33
- Letek, Michal, González, Patricia, MacArthur, Iain, Rodríguez, Héctor, Freeman, Tom C., Valero-Rello, Ana, Blanco, Mónica, Buckley, Tom, Cherevach, Inna, Fahey, Ruth, Hapeshi, Alexia, Holdstock, Jolyon, Leadon, Desmond, Navas, Jesús, Ocampo, Alain, Quail, Michael A., Sanders, Mandy, Scortti, Mariela M., Prescott, John F., Fogarty, Ursula, Meijer, Wim G., Parkhill, Julian, Bentley, Stephen D., Vázquez-Boland, José A., 2010. The genome of a pathogenic rhodococcus : cooptive virulence underpinned by key gene acquisitions. PLoS Genetics, 6 (9)