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Metabolic & Genetic Circuits


We are working on an interesting issue on two circuits: one for nutrition and the other for genetics. Working with Prof. Jin Li, Prof. Lin Wei, both from Fudan, and others, we are investigating how the lack of folate could cause neuronal tube defect (NTD).

circuits.pngFigure: A folate circuit (from http://labs.fhcrc.org/ulrich/metabolism/index.html). We have MS/MS data from control and NTD cases for 11 metabolites and we are working on comparing the differences in the circuit between two cases, with the aim to explore the underlying mechanisms and develop medical treatments.