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Introduction

Glands are important histological structures which are present in most organ systems as the main mechanism for secreting proteins and carbohydrates. It has been shown that malignant tumours arising from glandular epithelium, also known as adenocarcinomas, are the most prevalent form of cancer. The morphology of glands has been used routinely by pathologists to assess the degree of malignancy of several adenocarcinomas, including prostate, breast, lung, and colon.

Accurate segmentation of glands is often a crucial step to obtain reliable morphological statistics. Nonetheless, the task by nature is very challenging due to the great variation of glandular morphology in different histologic grades. Up until now, the majority of studies focus on gland segmentation in healthy or benign samples, but rarely on intermediate or high grade cancer, and quite often, they are optimised to specific datasets.

In this challenge, participants are encouraged to run their gland segmentation algorithms on images of Hematoxylin and Eosin (H&E) stained slides, consisting of a variety of histologic grades. The dataset is provided together with ground truth annotations by expert pathologists. The participants are asked to develop and optimise their algorithms on the provided training dataset, and validate their algorithm on the test dataset.


Data Description

The challenge will be conducted on a dataset, acquired by a team of pathologists at the University Hospitals Coventry and Warwickshire, UK. Details of the dataset are as follows.

Dataset Warwick-QU

Cancer Type

Colorectal Cancer

Resolution/

Scanner

20X (0.62005 \mu{m}/pixel)

Zeiss MIRAX MIDI

Number

of Images

165

Format

bmp


The composition of the dataset is as follows.

Split Warwick-QU
Training

benign : 37

malignant : 48

Test

benign : 37

malignant : 43


The ground truth for each image in the training dataset is stored in a BMP file, one ground truth object per label.


Challenge Tasks

After registration, the team will receive a username and password for downloading the training datasets. Each team are asked to submit a short paper, which includes a description of their segmentation algorithm and some preliminary results on the training dataset. See submission section for more details. Teams that have submitted a short paper will be invited to present their work at GlaS challenge at MICCAI 2015. The test dataset will be made available upon the acceptance of your invitation. The organisers will evaluate the performance of a segmentation algorithm based on the test datasets and announce the final competition result at the GlaS Challenge event.



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