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Dr Amol Bhandare

Job Title
Research Fellow
Department
Life Sciences
Phone
+44 247 65 22697
Research Interests

Microglia are associated with the tripartite synapse, and provide trophic support for neurons, promote formation and function of synapses, prune synapses by phagocytosis, and fulfil a range of homeostatic maintenance functions. Dr Bhandare avails state-of-the-art in-vivo imaging and in-vitro molecular techniques to explore the functional role of microglia in healthy and diseased brain.

Anaesthesia depresses neural activity, therefore being able to image the neuronal network in an awake state offers therapeutic strategies to prevent seizures and sudden deaths in epilepsy. At Warwick, we are using highly advanced - head-mounted mini-camera - in freely behaving mice to image neurons in live animals. We have made the first-ever optical recording of cardiorespiratory neurons in conscious mice. We hope to prevent the failure of the cardiorespiratory neuronal networks during seizures through the modification of neuroglial activity. This will improve the quality of life of people suffering from epilepsy by lessening concerns over SUDEP.

Biography

Epilepsy Research UK (ERUK) Research Fellow at School of Life Sciences, University of Warwick, UK (2019-till now)

Postdoctoral Research Fellow at School of Life Sciences, University of Warwick, UK (2016-2019)

PhD in Neurosciences from Macquarie University Sydney, Australia (2013-2016)

Research Assistant at Department of Pharmacology, University of Virginia, USA (2012)

M.Pharm Pharmacology from University of Pune, India (2008-2010)

Member, Society for Neurosciences

Member, International Society for Neurochemistry

Member, Australian Society for Neurosciences

Title Funder Award start Award end
Do microglia prevent seizure-induced cardiorespiratory dysfunction in freely behaving mice? Full application Epilepsy Research UK 01 Oct 2019 31 Mar 2022

Research Themes:

Biomedical Science