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Dr Amol Bhandare

Job Title
Research Fellow
Department
Life Sciences
Phone
+44 247 65 22697
Research Interests

Microglia are associated with the tripartite synapse, and provide trophic support for neurons, promote formation and function of synapses, prune synapses by phagocytosis, and fulfil a range of homeostatic maintenance functions. Dr Bhandare avails state-of-the-art in-vivo imaging and in-vitro molecular techniques to explore the functional role of microglia in healthy and diseased brain.

Anaesthesia depresses neural activity, therefore being able to image the brainstem cardiorespiratory neuronal network and beneficial effects of microglial activation or inhibition during seizures in freely behaving animal offers therapeutic strategies to prevent cardiorespiratory failure and sudden deaths in epilepsy. At Warwick, we are using highly advanced - head mounted mini-camera - in freely behaving mice to image cardiorespiratory brainstem neurons in live animals. We have made the first ever optical recording of cardiorespiratory neurons in conscious mice. Our expertise allow us to address the role of microglia in sudden unexpected death in epilepsy (SUDEP) by imaging cardiorespiratory neurons, manipulating microglia and simultaneously measuring epileptic seizures in awake mice. We hope to prevent the failure of cardiorespiratory neuronal network during seizures through modification of microglial activity. This will improve the quality of life of people suffering from epilepsy by lessening concerns over SUDEP.

Biography

Epilepsy Research UK (ERUK) Research Fellow at School of Life Sciences, University of Warwick, UK (2019-till now)
Postdoctoral Research Fellow at School of Life Sciences, University of Warwick, UK (2016-2019)
PhD in Neurosciences from Macquarie University Sydney, Australia (2013-2016)
Research Assistant at Department of Pharmacology, University of Virginia, USA (2012)
M.Pharm Pharmacology from University of Pune, India (2008-2010)

Member, Society for Neurosciences
Member, International Society for Neurochemistry
Member, Australian Society for Neurosciences

Title Funder Award start Award end
Do microglia prevent seizure-induced cardiorespiratory dysfunction in freely behaving mice? Full application Epilepsy Research UK 01 Oct 2019 30 Sep 2021


Research Themes:

Biomedical Science