Cardiorespiratory autonomic system is essential for the maintenance of normal blood pressure, excretion of carbon dioxide and intake of oxygen. The system is controlled by nuclei present in the brainstem such as RVLM, CVLM, NTS, RTN, pre-Böt, Böt etc. The different disease conditions, such as epilepsy and sleep apnea, disturb the normal cardiorespiratory autonomic function, which can also lead to a death.
My current work is focused on in vivo imaging of single neuron to understand the role of ATP in central chemosensory control of breathing using genetically encoded fluorescent reporters and Gradient Index (GRIN) optics in freely behaving animals. My interest also extends to understand the role of inflammation during epilepsy and sleep apnea and response of glia (microglia) and neuropeptides in the vicinity of cardiorespiratory autonomic nuclei to maintain the normal cardiorespiratory activity