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Dr Amol Bhandare

 

Title   

Research Fellow
 

Contact   

Life Sciences
University of Warwick
Coventry
CV4 7AL
Tel: +44 247 65 22697
Email: A.Bhandare@warwick.ac.uk

Research Interests

Microglia are associated with the tripartite synapse, and provide trophic support for neurons, promote formation and function of synapses, prune synapses by phagocytosis, and fulfil a range of homeostatic maintenance functions. Dr Bhandare avails state-of-the-art in-vivo imaging and in-vitro molecular techniques to explore the functional role of microglia in healthy and diseased brain.

Anaesthesia depresses neural activity, therefore being able to image the brainstem cardiorespiratory neuronal network and beneficial effects of microglial activation or inhibition during seizures in freely behaving animal offers therapeutic strategies to prevent cardiorespiratory failure and sudden deaths in epilepsy. At Warwick, we are using highly advanced - head mounted mini-camera - in freely behaving mice to image cardiorespiratory brainstem neurons in live animals. We have made the first ever optical recording of cardiorespiratory neurons in conscious mice. Our expertise allow us to address the role of microglia in sudden unexpected death in epilepsy (SUDEP) by imaging cardiorespiratory neurons, manipulating microglia and simultaneously measuring epileptic seizures in awake mice. We hope to prevent the failure of cardiorespiratory neuronal network during seizures through modification of microglial activity. This will improve the quality of life of people suffering from epilepsy by lessening concerns over SUDEP.


Biography

Epilepsy Research UK (ERUK) Research Fellow at School of Life Sciences, University of Warwick, UK (2019-till now)
Postdoctoral Research Fellow at School of Life Sciences, University of Warwick, UK (2016-2019)
PhD in Neurosciences from Macquarie University Sydney, Australia (2013-2016)
Research Assistant at Department of Pharmacology, University of Virginia, USA (2012)
M.Pharm Pharmacology from University of Pune, India (2008-2010)

Member, Society for Neurosciences
Member, International Society for Neurochemistry
Member, Australian Society for Neurosciences

Research Projects

View Current Projects        View All Projects

Publications

Journals
  • Bhandare, Amol M., Kapoor, Komal, Powell, Kim L., Braine, Emma, Casillas-Espinosa, Pablo, O'Brien, Terence J., Farnham, Melissa M. J., Pilowsky, Paul M., 2017. Inhibition of microglial activation with minocycline at the intrathecal level attenuates sympathoexcitatory and proarrhythmogenic changes in rats with chronic temporal lobe epilepsy. Neuroscience, 350, pp. 23-38, View
  • Bhandare, Amol M., Kapoor, Komal, Farnham, Melissa M. J., Pilowsky, Paul M., 2016. Microglia PACAP and glutamate : friends or foes in seizure-induced autonomic dysfunction and SUDEP?. Respiratory Physiology & Neurobiology, 226, pp. 39-50, View
  • Kapoor, Komal, Bhandare, Amol M., Nedoboy, Polina E., Mohammed, Suja, Farnham, Melissa M. J., Pilowsky, Paul M., 2016. Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure. Neuroscience, 329, pp. 12-29, View
  • Kapoor, Komal, Bhandare, Amol M., Mohammed, Suja, Farnham, Melissa M.J., Pilowsky, Paul M., 2016. Microglial number is related to the number of tyrosine hydroxylase neurons in SHR and normotensive rats. Autonomic Neuroscience, 198, pp. 10-18, View
  • Bhandare, Amol M., Kapoor, K., Pilowsky, P. M., Farnham, Melissa M. J., 2016. Seizure-induced sympathoexcitation is caused by activation of glutamatergic receptors in RVLM that also causes proarrhythmogenic changes mediated by PACAP and microglia in rats. Journal of Neuroscience, 36 (2), pp. 506-517, View
  • Kapoor, Komal, Bhandare, Amol M., Farnham, Melissa M. J., Pilowsky, Paul M., 2016. Alerted microglia and the sympathetic nervous system : a novel form of microglia in the development of hypertension. Respiratory Physiology & Neurobiology, 226, pp. 51-62, View
  • Nedoboy, P. E., Mohammed, S., Kapoor, K., Bhandare, Amol M., Farnham, M. M. J., Pilowsky, P. M., 2016. pSer40 tyrosine hydroxylase immunohistochemistry identifies the anatomical location of C1 neurons in rat RVLM that are activated by hypotension. Neuroscience, 317, pp. 162-172, View
  • Bhandare, Amol M., Mohammed, S., Pilowsky, P. M., Farnham, M. M. J., 2015. Antagonism of PACAP or microglia function worsens the cardiovascular consequences of kainic-acid-induced seizures in rats. Journal of Neuroscience, 35 (5), pp. 2191-2199, View

View All Publications

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Research Themes:

Biomedical Science