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Dr Anne-Claire Jacomin

 

Title   

Research Fellow
 

Contact   

Life Sciences
University of Warwick
Coventry
CV4 7AL
Tel: +44(0) 24765 74247
Email: A-C.M.Jacomin@warwick.ac.uk

Research Interests

Research fellow: Autophagy in Health and Disease group

My research interests focus in identifying and understanding the function of novel selective autophagy-associated proteins using the powerful non-mammalian model organism Drosophila melanogaster. Autophagy is one of the major degradation pathways of the cell whose components and mechanism are evolutionary conserved. Firstly described as a bulk and unspecific process, there is increasing evidence that autophagy occurs in a selective manner and that the targeting of various substrates to autophagosomes involves several specific adaptor proteins that their function remains to be discovered.

I did my PhD in the group of Marie-Odile Fauvarque in Grenoble,France. The subject of my thesis was to decipher the function of deubiquitinating enzymes involved in pro-inflammatory response and autophagy. The first part of my work was related to the function of the deubiquitinating enzyme USP36 in the negative regulation of the immune pathway depending on the TNF-associated receptor 1 (TNF-R1) pathway in human cultured cells using cellular and biochemical approaches. In the second part of my work, I performed a genetic screen in vivo in Drosophila for the identification of deubiquitinating enzymes involved in the regulation of autophagy. I identified two enzymes whose loss-of-function affects the progression of both autophagy and endocytosis. Further investigations allowed us to establish that an intact endocytic pathway is required for productive autophagy.


Biography

2010 - 2014: PhD, Cell biology, University Grenoble-Alpes, Grenoble, FRANCE
2008 - 2010: MSc, Integrative Cell Biology, University Joseph Fourier, Grenoble, FRANCE
2005 - 2008: BSc, Biology, University Joseph Fourier, Grenoble, FRANCE

Member, French Club of Autophagy (CFATG)
Member, Royal Society of Biology
Member, Biochemical Society

Publications

Journals
  • Jacomin, Anne-Claire, Fauvarque, Marie-Odile, Taillebourg, Emmanuel, 2016. A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila. BMC Cell Biology, 17 (1), View
  • Jacomin, Anne-Claire, Samavedam, Siva, Promponas, Vasilis, Nezis, I. P., 2016. iLIR database : a web resource for LIR motif-containing proteins in eukaryotes. Autophagy, 12 (10), pp. 1945-1953, View
  • Jacomin, Anne-Claire, Bescond, Amandine, Soleilhac, Emmanuelle, Gallet, Benoà®t, Schoehn, Guy, Fauvarque, Marie-Odile, Taillebourg, Emmanuel, 2015. The deubiquitinating enzyme UBPY is required for Lysosomal Biogenesis and productive autophagy in drosophila. PLoS One, 10 (11), View
  • Taillebourg, Emmanuel, Gregoire, Isabel, Viargues, Perrine, Jacomin, Anne-Claire, Thevenon, Dominique, Faure, Mathias, Fauvarque, Marie-Odile, 2012. The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Autophagy, 8 (5), pp. 767-779, View

View All Publications

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Research Themes:

Biomedical Science