Job Title
Associate Professor (Research Focussed)
Department
Life Sciences
Phone
76522568
- 'Dowson, Amanda J., 'Lloyd, Adrian J., 'Cuming, Andrew C., 'Roper, David I., 'Frigerio, Lorenzo, 'Dowson, Christopher G., 2022. 'Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1), pp. 165-179
- Aggarwal, Surya D., Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R, Hiller, N Luisa, 2021. A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14)
- York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, Fülöp, Vilmos, Dowson, Christopher G., Khalid, Syma, Roper, David I., 2021. Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7), pp. 731-742
- Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I., Dowson, Christopher G., 2020. Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11), pp. 5034-5048
- Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J., Roper, David I., 2019. Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21), pp. 9703-9717
- Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma, Roper, David I., 2018. The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2, pp. 54-66
- Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R., 2018. Structural studies suggest aggregation as one of the modes of action for teixobactin. Chemical Science, 9 (47), pp. 8850-8859
- Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, Ko?mrlj, Janez, Dowson, Christopher G., 2017. Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127, pp. 223-234
- Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S., Roper, David I., 2017. Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1)
- Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A., Besra, Gurdyal S., 2016. Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6
- Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh et al (Select to open full list), 2015. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6, pp. 1-11
- Gurcha, Sudagar S., Usha, Veeraraghavan, Cox, Jonathan A. G., Fütterer, Klaus, Abrahams, Katherine A., Bhatt, Apoorva, Alderwick, Luke J., Reynolds, Robert C., Loman, Nicholas J., Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J., Ballell, Lluis, Hobrath, Judith V., Besra, Gurdyal S., 2014. Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target. PLoS One, 9 (11)
- Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I., Dowson, Christopher G., 2013. Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10), pp. 2157-2163
- Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I., Dowson, Christopher G., 2013. Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10), pp. 2157-2163
- Valegård, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, Généreux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger, McDonough, Michael A., 2013. Structural and mechanistic studies of theorf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica Section D Biological Crystallography, 69 (8), pp. 1567-1579
- Ruane, Karen M., Lloyd, Adrian J., Fülöp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa, Roper, David I., 2013. Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, 288 (46)
- Usha, Veeraraghavan, Lloyd, Adrian, Lovering, Andrew L., Besra, Gurdyal S., 2012. Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. FEMS Microbiology Letters, Vol.330 (No.1), pp. 10-16
- Alderwick, Luke J., Lloyd, Georgina S., Lloyd, Adrian, Lovering, Andrew L., Eggeling, L., Besra, Gurdyal S., 2011. Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase. Glycobiology, Vol.21 (No.4), pp. 410-425
- Usha, Veeraraghavan, Gurcha, Sudagar S., Lovering, Andrew L., Lloyd, Adrian, Papaemmanouil, A., Reynolds, Robert C., Besra, Gurdyal S., 2011. Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology, Vol.157 (No.1), pp. 290-299
- Lloyd, Amanda J., William Allwood, J., Winder, Catherine L., Dunn, Warwick B., Heald, James K., Cristescu, Simona M., Sivakumaran, Anushen, Harren, Frans J. M., Mulema, Joseph M. K., Denby, Katherine J., Goodacre, Royston, Smith, Aileen R., Mur, Luis A. J., 2011. Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against Botrytis cinerea. The Plant Journal, Vol.67 (No.5), pp. 852-868
- Coker, Shu-Fen, Lloyd, Adrian J., Mitchell, Edward, Lewis, Gareth R., Coker, Alun R., Shoolingin-Jordan, Peter M., 2010. The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase. Acta Crystallographica Section D Biological Crystallography, Vol.66 (No.7), pp. 797-805
- Sova, Matej, Cadez, Gasper, Turk, Samo, Majce, Vita, Polanc, Slovenko, Batson, Sarah, Lloyd, Adrian, Roper, David I., Fishwick, Colin W. G., Gobec, Stanislav, 2009. Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorganic & Medicinal Chemistry Letters, Vol.19 (No.5), pp. 1376-1379
- Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G., Bugg, Tim, 2009. Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9), pp. 3443-3455
- Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim, Levesque, Roger C., 2009. Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2), pp. 263-272
- Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I., Dowson, Christopher G., 2008. Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10), pp. 6402-6417
- Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim, Levesque, Roger C., 2008. Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC Biochemistry, Vol.9 (No.33)
- De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G., Bugg, Tim, 2008. Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50), pp. 34571-34579
- Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G., Bugg, Tim, 2007. Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16), pp. 4654-4656
- Tötemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan, Bryant, Clare, 2006. IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8), pp. 4804-4810
- Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Lloyd, Adrian J., Besra, Gurdyal S., 2006. Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase. FEMS Microbiology Letters, 262 (1), pp. 39-47
- Paradis-Bleau , Catherine, Beaumont, Mélanie, Boudreault, Lydia, Lloyd, Adrian, Sanschagrina, François, Bugg, Tim, Levesquea, Roger C., 2006. Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. Peptides, 27 (7), pp. 1693-1700
- Kishida, H., Unzai, Satoru, Roper, David I., Lloyd, A, Park, S.Y., Tame, Jeremy R. H., 2006. Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry, Vol.45 (No.3), pp. 783-792
- 'Schouten, James A., 'Bagga, Sangeev, 'Lloyd, Adrian J., 'De Pascale, Gianfranco, 'Dowson, Christopher G., 'Roper, David I., 'Bugg, Timothy D. H., 2006. 'Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.. Molecular BioSystems, 2 (10), pp. 484-491
- 'Bugg, Timothy D. H., 'Lloyd, Adrian J., 'Roper, David I., 2006. 'Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. Infectious Disorders - Drug Targets, 6 (2), pp. 85-106
- 'Besong, Gilbert E., 'Bostock, Julieanne M., 'Stubbings, Will, 'Chopra, Ian, 'Roper, David I., 'Lloyd, Adrian J., 'Fishwick, Colin W. G., 'Johnson, A. Peter, 2005. 'A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Angewandte Chemie (International Edition), 44 (39), pp. 6403-6406
- 'Lloyd, Adrian J., 'Brandish, Philip E., 'Gilbey, Andrea M., 'Bugg, Timothy D. H., 2004. 'Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli : catalytic role of conserved aspartic acid residues. Journal of bacteriology, 186 (6), pp. 1747-57
- 'Lloyd, Adrian J., 'Shoolingin-Jordan, P. M., 2001. 'Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis. Biochemistry, 40 (8), pp. 2455-2467
- 'Shoolingin-Jordan, Peter M., 'LeLean, Jeremy E., 'Lloyd, Adrian J., 1997. 'Continuous coupled assay for 5-aminolevulinate synthase. Methods in Enzymology, 281, pp. 309-316
- 'Lloyd, Adrian J., 'Thomann, H. U., 'Ibba, M., 'Söll, D., 1995. 'A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-tRNA synthetase activity. Nucleic Acids Research, 23 (15), pp. 2886-2892
- 'Stange-Thomann, N., 'Thomann, H. U., 'Lloyd, Adrian J., 'Lyman, H., 'Söll, D., 1994. 'A point mutation in Euglena gracilis chloroplast tRNA(Glu) uncouples protein and chlorophyll biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 91 (17), pp. 7947-7951
- 'Lloyd, Adrian J., 'Gray, R. G., 'Green, A, 1994. 'Tyrosinaemia type 1 and glutathione synthetase deficiency : two disorders with reduced hepatic thiol group concentrations and a liver 4-fumarylacetoacetate hydrolase deficiency. Journal of Inherited Metabolic Disease, 18 (1), pp. 48-55
- 'Lloyd, Adrian J., 'Weitzman, P. D., 'Soll, D., 1993. 'Incomplete citric acid cycle obliges aminolevulinic acid synthesis via the C5 pathway in a methylotroph. Journal of General Microbiology, 139 (12), pp. 2931-2938
- 'Lloyd, Adrian J., 'Weitzman, P. D. J., 1988. 'Purification and characterization of NAD-linked isocitrate dehydrogenase from Methylophilus methylotrophus. Biochemical Society Transactions, 16 (5), pp. 871-872
- 'Lloyd, Adrian J., 'Weitzman , P. D. J., 1987. 'Modification of the regulatory properties of Acinetobacter citrate synthase by cross-linking. Biochemical Society Transactions, 15 (5)
- 'Verkamp, Elizabeth, 'Kumar, A. Madan, 'Lloyd, Adrian J., 'Martins, Orlando, 1994. 'Glutamyl-tRNA as an intermediate in Glutamate conversions. In Söll, Dieter; RajBhandary, Uttam L. (eds.), tRNA: Structure, Biosynthesis, and Function, Washington DC, ASM Press, pp. 545-550
- 'Griffiths, E. J., 'Lloyd, Adrian J., 'Brunt, R. V., 1991. 'Effect of ischaemia and reperfusion on lipid metabolism and glycogenolysis in hearts from normal and diabetic rats. Nagano, M.; Dhalla, N. (eds.), The Diabetic Heart, New York, Raven Press
- Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R., 2018. Data for Structural studies suggest aggregation as one of the modes of action for teixobactin. Department of Chemistry, University of Warwick
- Lloyd, Adrian, 2008. Making resistance futile - targeting penicillin resistant super-bug infections. University of Warwick, Communications Office
- 'Lloyd, Adrian J., 'Huyton, Trevor, 'Turkenburg, Johan, 'Roper, David I., 2004. 'Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis. Acta crystallographica. Section D, Biological crystallography, Wiley, pp. 397-400
| Title | Funder | Award start | Award end |
|---|---|---|---|
| MRC UK China Hubs | MRC | 01 Jan 2019 | 31 Mar 2022 |
| Mechanistic understanding of cell wall biosynthesis to combat antimicrobial resistance: Cell Wall AMR | MRC | 01 Jul 2015 | 28 Aug 2021 |
| Multi-Targetting of tRNA synthetases: A paradigm shift in combating AMR | MRC | 01 Mar 2015 | 30 Nov 2017 |
| Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis | MRC | 01 Jan 2012 | 31 Dec 2015 |
| BBSRC Link with Astra Zeneca:Reagents and assays to exploit the final steps of peptidoglycan construction | BBSRC | 01 Aug 2013 | 31 Jul 2015 |
| The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant | MRC | 01 May 2011 | 30 Apr 2014 |
| Unesco- loreal Visiting Fellowship for Vita Majce | UNESCO | 01 May 2012 | 30 Apr 2013 |
| Exploration and translational exploitation of mycobacterial cell wall synthesis and regulation | Medical Research Fund of Warwick | 01 Feb 2010 | 31 Jan 2011 |
| UK - BaCWAN: UK-Bacterial Cell Wall Assembly Network | MRC | 01 Apr 2006 | 31 Mar 2008 |
| Exploration and Exploitation of the Enzymology of PBP Driven Peptidoglycan Biosynthesis to Discover Novel Non-beta Lactam Antibiotics | MRC | 01 Mar 2005 | 29 Feb 2008 |