Skip to main content Skip to navigation

Dr Byron Carpenter

Job Title
Research Fellow
Department
Life Sciences
Phone
024 765 74242
Research Interests

WISB Research Career Development Fellow

G protein-coupled receptors (GPCRs) are transmembrane proteins that regulate cytoplasmic signalling through heterotrimeric G proteins and arrestins. There are approximately 800 GPCRs encoded by the human genome that respond to a vast array of extracellular stimuli, including light, odorants, hormones and neurotransmitters. Their integral role in regulating a wide variety of cellular responses makes these receptors important therapeutic targets, and it is estimated that 40% of current prescription medicines modulate GPCR signalling.

My research has focused on the developed an engineered minimal G protein to facilitate the crystallisation and structure determination of GPCR-G protein complexes. My current research aims to understand the mechanism of G protein activation, molecular determinants of G protein specificity and kinetics of signal transduction.

Biography

WISB Research Career Development Fellow, University of Warwick, since 2016
Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, 2012-2016
MRC Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge, 2009-2012
PhD Structural Biology, University of Sheffield, 2006-2009
BSc Biochemistry, University of Wales Cardiff, 2001-2004

Member, Biochemical Society, since 2010


Research Themes:

Biotechnology