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Dr Byron Carpenter

Job Title
Research Fellow
Department
Life Sciences
Phone
024 765 74242
Research Interests

WISB Research Career Development Fellow

G protein-coupled receptors (GPCRs) are transmembrane proteins that regulate cytoplasmic signalling through heterotrimeric G proteins and arrestins. There are approximately 800 GPCRs encoded by the human genome that respond to a vast array of extracellular stimuli, including light, odorants, hormones and neurotransmitters. Their integral role in regulating a wide variety of cellular responses makes these receptors important therapeutic targets, and it is estimated that 40% of current prescription medicines modulate GPCR signalling.

My research has focused on the developed an engineered minimal G protein to facilitate the crystallisation and structure determination of GPCR-G protein complexes. My current research aims to understand the mechanism of G protein activation, molecular determinants of G protein specificity and kinetics of signal transduction.

Biography

WISB Research Career Development Fellow, University of Warwick, since 2016
Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, 2012-2016
MRC Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge, 2009-2012
PhD Structural Biology, University of Sheffield, 2006-2009
BSc Biochemistry, University of Wales Cardiff, 2001-2004

Member, Biochemical Society, since 2010

Title Funder Award start Award end
Developing a synthetic signalling system capable of the precise spatial and temporal control of protein function in living cells. UKRI FLF UK Research and Innovation 01 Oct 2020 30 Sep 2024


Research Themes:

Biotechnology