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Publications

 

 2018

  • Menon, Binuraj R. K., Jenner, Matthew. 2018. Biosynthesis : reprogramming assembly lines. Nature Chemistry, 10 (3), pp. 245-247, Viewcv1
  • Bennett, Matthew R., Thompson, Mark L., Shepherd, Sarah A., Dunstan, Mark S., Herbert, Abigail J., Smith, Duncan R. M., Cronin, Victoria A., Menon, Binuraj R. K., Levy, Colin, Micklefield, Jason. 2018.. Angewandte Chemie International Edition, View

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2017

  • Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason. 2017. RadH : a versatile halogenase for integration into synthetic pathways. Angewandte Chemie International Edition, 56 (39), pp. 11841-11845, View

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  • Latham, Jonathan, Brandenburger, Eileen, Shepherd, Sarah A., Menon, Binuraj R. K., Micklefield, Jason. 2017. Development of halogenase enzymes for use in synthesis. Chemical Reviews, View

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2016

  • Latham, Jonathan, Henry, Jean-Marc, Sharif, Humera H., Menon, Binuraj R. K., Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason. 2016. Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation. Nature Communications, 7, View

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  • Menon, Binuraj R. K., Latham, Jonathan, Dunstan, Mark S., Brandenburger, Eileen, Klemstein, Ulrike, Leys, David, Karthikeyan, Chinnan, Greaney, Michael F., Shepherd, Sarah A., Micklefield, Jason. 2016. Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic and Biomolecular Chemistry, 14 (39), pp. 9354-9361, View untitled.png
  • Menon, Binuraj R. K., Hardman, Samantha J. O., Scrutton, Nigel S., Heyes, Derren J.. 2016. Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR). Journal of Photochemistry and Photobiology B: Biology, 161, pp. 236-243, View

 cv6 

  • Shepherd, Sarah A., Menon, Binuraj R. K., Fisk, Heidi, Struck, Anna-Winona, Levy, Colin, Leys, David, Micklefield, Jason. 2016. A structure-guided switch in the regioselectivity of a tryptophan halogenase. Chembiochem, 17 (9), pp. 821-824, View

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  • Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam, Leys, David. 2016. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme. Nature, 539 (7630), pp. 593-597, View

 cv8 

2015

  • Menon, Navya, Pásztor, András, Menon, Binuraj R. K., Kallio, Pauli, Fisher, Karl, Akhtar, M. Kalim, Leys, David, Jones, Patrik R., Scrutton, Nigel S.. 2015. A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnology for Biofuels, 8 (1), View

 cv8

 

  • Shepherd, Sarah A., Karthikeyan, Chinnan, Latham, Jonathan, Struck, Anna-Winona, Thompson, Mark L., Menon, Binuraj R. K., Styles, Matthew Q., Levy, Colin, Leys, David, Micklefield, Jason. 2015. Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. Chemical Science, 6 (6), pp. 3454-3460, View
  • cvb
  • Menon, Binuraj R. K., Menon, Navya, Fisher, Karl, Rigby, Stephen E. J., Leys, David, Scrutton, Nigel S.. 2 015. Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase. FEBS Journal, 282 (7), pp. 1242-1255, Viewcvb

2014-2009

  • Menon, Binuraj R. K., Fisher, Karl, Rigby, Stephen E. J., Scrutton, Nigel S., Leys, David. 2014. A conformational sampling model for radical catalysis in pyridoxal phosphate- and cobalamin-dependent enzymes. Journal of Biological Chemistry, 289 (49), pp. 34161-34174, View

f11 

  • Menon, Binuraj R. K., Waltho, Jonathan P., Scrutton, Nigel S., Heyes, Derren J.. 2009. Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 284 (27), pp. 18160-18166, View

 pro

  • Menon, Binuraj R. K., Davison, Paul A., Hunter, C. Neil, Scrutton, Nigel S., Heyes, Derren J.. 2009. Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 285 (3), pp. 2113-2119, Viewuntitled2.png
  • Heyes, Derren J., Menon, Binuraj R. K., Sakuma, Michiyo, Scrutton, Nigel S.. 2008. Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase. Biochemistry, 47 (41), pp. 10991-10998, View

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