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Dr Eleanor Jameson

Job Title
Research Fellow
Department
Life Sciences
Phone
024 765 73488
Research Interests

WISB Research Career Development Fellow, 2017 to present

I am working on gut-associated bacteriophage, which have the potential to manipulate the gut microbiome, but remain under-studied. Gram negative bacteria, particularly *Klebsiella spp.*contribute to metabolic syndrome-associated TMA production in the gut. The substrates for TMA production come from the diet, particularly from meat and dairy products. The bacterial metabolic pathways for TMA production are understood for the pre-cursors choline, carnitine and glycine betaine and my research has revealed which bacteria contain these pathways. Phage are known to be in approximately equal proportions to bacteria in human feaces and have the potential to lyse their bacterial host. There is a gap in current knowledge; gut phage and bacteria have been well catalogued, however there remains a lack of understanding of functional metabolism and phage-bacteria-host interactions.
My fellowship focuses on phage-host interaction in the gut microbiome and their impacts on human health and disease. Phage have the potential as an alternative or complement to antibiotics. I work with both aerobic and anaerobic culturing of facultative anaerobes, using targeted mutagenesis, Next Generation sequencing, functional gene analysis, flow cytometery and ion chromatography. One aspect of my work involves the bacterial metabolism of quaternary amines and production of proatherosclerosis-associated trimethylamine (TMA). I am also interested in the impact of phage on general human health and the role they play in antibiotic resistance.

Biography

Post-doctoral research fellow, The University of Warwick, 2012-2016. Anaerobic degradation of quaternary amines to TMA.

Post-doctoral research fellow, The University of Exeter, 2008-2011. Shell funded, cyanobacteria-based biofuels.

Post-doctoral researcher, Bangor University, 2008. European BioMinE project, Selectively recover metals from mine waste.

PhD, Plymouth Marine Laboratory/The University of Warwick, 2004-2008. Molecular studies on the diversity of the marine cyanobacteria Prochlorococcus and their co-occurring phages.

BSc, The University of Liverpool, Marine Biology, 1999-2002.

Member: SfAM and the Microbiology Society.

Title Funder Award start Award end
Natural phages to inhibit bacterial-associated cardiovascular diseases (Eleanor Townsend) Medical and Life Sciences Research Fund 01 Feb 2020 31 Jul 2020