WISB Research Career Development Fellow, 2017 to present
I am working on gut-associated bacteriophage, which have the potential to manipulate the gut microbiome, but remain under-studied. Gram negative bacteria, particularly *Klebsiella spp.*contribute to metabolic syndrome-associated TMA production in the gut. The substrates for TMA production come from the diet, particularly from meat and dairy products. The bacterial metabolic pathways for TMA production are understood for the pre-cursors choline, carnitine and glycine betaine and my research has revealed which bacteria contain these pathways. Phage are known to be in approximately equal proportions to bacteria in human feaces and have the potential to lyse their bacterial host. There is a gap in current knowledge; gut phage and bacteria have been well catalogued, however there remains a lack of understanding of functional metabolism and phage-bacteria-host interactions.
My fellowship focuses on phage-host interaction in the gut microbiome and their impacts on human health and disease. Phage have the potential as an alternative or complement to antibiotics. I work with both aerobic and anaerobic culturing of facultative anaerobes, using targeted mutagenesis, Next Generation sequencing, functional gene analysis, flow cytometery and ion chromatography. One aspect of my work involves the bacterial metabolism of quaternary amines and production of proatherosclerosis-associated trimethylamine (TMA). I am also interested in the impact of phage on general human health and the role they play in antibiotic resistance.
Post-doctoral research fellow, The University of Warwick, 2012-2016. Anaerobic degradation of quaternary amines to TMA.
Post-doctoral research fellow, The University of Exeter, 2008-2011. Shell funded, cyanobacteria-based biofuels.
Post-doctoral researcher, Bangor University, 2008. European BioMinE project, Selectively recover metals from mine waste.
PhD, Plymouth Marine Laboratory/The University of Warwick, 2004-2008. Molecular studies on the diversity of the marine cyanobacteria Prochlorococcus and their co-occurring phages.
BSc, The University of Liverpool, Marine Biology, 1999-2002.
Member: SfAM and the Microbiology Society.
- Jameson, Eleanor, Stephenson, Jason, Jones, Helen J., Millard, Andrew D., Kaster, K., Purdy, Kevin J., Airs, R., Murrell, J. C. (J. Colin), Chen, Yin, 2019. Deltaproteobacteria (Pelobacter) and Methanococcoides are responsible for choline-dependent methanogenesis in a coastal saltmarsh sediment. ISME Journal, 13 (2), pp. 277-289
- Michniewski, Slawomir, Redgwell, Tamsin, Grigonyte, Aurelija, Rihtman, Branko, Aguilo-Ferretjans, Maria, Christie-Oleza, Joseph, Jameson, Eleanor, Scanlan, David J., Millard, Andrew D., 2019. Riding the wave of genomics to investigate aquatic coliphage diversity and activity. Environmental Microbiology, 21 (6), pp. 2112-2128
- Chen, Yin, Jones, Helen J., Kröber, Eileen, Stephenson, Jason, Mausz, Michaela A., Jameson, Eleanor, Millard, Andrew D., Purdy, Kevin J., 2019. A new family of uncultivated bacteria involved in methanogenesis from the ubiquitous osmolyte glycine betaine in coastal saltmarsh sediments. Microbiome, 7
- Jameson, Eleanor, Quareshy, Mussa, Chen, Yin, 2018. Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut. Methods, 149, pp. 42-48
- Jameson, Eleanor, Doxey, Andrew C., Airs, Ruth, Purdy, Kevin J., Murrell, J. C. (J. Colin), Chen, Yin, 2016. Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems. Microbial Genomics, 2 (9)
- Jameson, Eleanor, Fu, Tiantian, Brown, Ian R., Paszkiewicz, Konrad, Purdy, Kevin J., Frank, Stefanie, Chen, Yin, 2015. Anaerobic choline metabolism in microcompartments promotes growth and swarming of Proteus mirabilis. Environmental Microbiology, 18, pp. 2886-2898
- Zhu, Yijun, Jameson, Eleanor, Cosatti, Marialuisa, Schäfer, Hendrik, Rajakumar, Kumar, Bugg, Tim, Chen, Yin, 2014. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proceedings of the National Academy of Sciences of the United States of America, 111 (11), pp. 4268-4273
- Zhu, Yijun, Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Tim, Schäfer, Hendrik, Chen, Yin, 2014. Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. Environmental Microbiology, 16 (10), pp. 3318-3330
- Jameson, Eleanor, Mann, Nicholas H., Joint, Ian, Sambles, Christine, Mühling, Martin, 2011. The diversity of cyanomyovirus populations along a North?South Atlantic Ocean transect. The ISME Journal, 5 (11), pp. 1713-1721
- Jameson, Eleanor, Joint, Ian, Mann, Nicholas H., Muehling, Martin, 2010. Detailed analysis of the microdiversity of Prochlorococcus populations along a north-south Atlantic ocean transect. Environmental Microbiology, Vol.12 (No.1), pp. 156-171
- Jameson, E., Rowe, O. F., Hallberg, K. B., Johnson, D. B., 2010. Sulfidogenesis and selective precipitation of metals at low pH mediated by Acidithiobacillus spp. and acidophilic sulfate-reducing bacteria. Hydrometallurgy, 104 (3-4), pp. 488-493
- Johnson, D. Barrie, Jameson, E., Rowe, O. F., Wakeman, K., Hallberg, Kevin B., 2009. Sulfidogenesis at low pH by acidophilic bacteria and its potential for the selective recovery of transition metals from mine waters. Advanced Materials Research, 71-73, pp. 693-696
- Jameson, Eleanor, Joint, Ian, Mann, Nicholas H., Muehling, Martin, 2008. Application of a novel rpoC1-RFLP approach reveals that marine Prochlorococcus populations in the atlantic gyres are composed of greater microdiversity than previously described. Microbial Ecology, Vol.55 (No.1), pp. 141-151
- Jameson, Eleanor, Taubert, M., Coyotzi, S., Chen, Y., Eyice, O., Schafer, H., Murrell, J. C. (J. Colin), Neufelf, J. D., Dumont, M. G., 2017. DNA-, RNA-, and protein-based stable-isotope probing for high-throughput biomarker analysis of active microorganisms. In Streit, Wolfgang R.; Daniel, Rolf (eds.), Metagenomics : Methods and Protocols, Methods in Molecular Biology, Clifton, N.J, Humana Press ; Springer, pp. 57-74
|Title||Funder||Award start||Award end|
|Natural phages to inhibit bacterial-associated cardiovascular diseases (Eleanor Townsend)||Medical and Life Sciences Research Fund||01 Feb 2020||31 Jul 2020|