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Dr Eugene Ryabov

Job Title
Senior Research Fellow
Department
Life Sciences
Phone
024 765 72537
Research Interests

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| Bee virus |

Viruses are intracellular pathogens which utilize protein synthesis machinery and other systems of host cells for replication and spread. In order to withstand virus infections, their hosts have developed antivirus defenses including innate and adaptive immune responses and RNA interference (RNAi). Viruses have evolved a variety of counter-defense strategies to withstand these responses. Viruses greatly affect physiology, development and evolution of their hosts, and therefore have a wide medical, ecological and social impact.

We are interested in the factors affecting virus-host interactions in insects and plants, including virus diversity, mechanisms of antivirus responses (innate immunity signaling pathways and RNAi). Our current BBSRC-funded project explores the effect of the mite, Varroa destructor , on the interaction between the honeybee (Apis mellifera) and its viruses. It includes the study of genetic variation of antivirus responses in the honeybee and the effect on virus diversity on the pathogenesis.

See BBSRC Insect Pollinators Initiative and the

David Evans Research Group

Biography

I began my research in Molecular Virology at Moscow State University (MSc,1991) and completed my PhD degree in Moscow in 1995. I then joined the Scottish Crop Research Institute (Dundee) to work on RNA movement functions of plant viruses. I then moved to HRI and subsequently University of Warwick. My research expanded to include plant antiviral defenses, in particular RNA silencing, and viral counter-defenses. In 2006, I then began my work on insect-virus interactions. This research focused on viruses of aphids and the honeybee, mechanisms of the antiviral responses, and the impact of viruses on the host physiology and development.

  • Ryabov, Eugene V., Taliansky, M., Robinson, David G., Waterhouse, P.M., Murant, A.F., de Zoeten, G.A., Falk, B.W., Vetten, H.J., Gibbs, M.J.. Genus Umbravirus. In King, A.M.Q.; Adams, M.J.; Carstens, E.; Lefkowitz, E.J. (eds.), Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Netherlands, Elsevier, pp. 1191-1195
  • Ryabov, Eugene V., 2008. Construction of infectious cDNA clones for RNA viruses: Turnip crinkle virus.. In Plant virology protocols: from virus sequence to protein function, Totowa, N.J, Humana Press, Inc, pp. 491-502
  • Taliansky, M., Ryabov, Eugene V., 2008. Umbravirus. In Mahy, Brian W. J.; Van Regenmortel, Marc H. V. (eds.), Encyclopedia of Virology, United Kingdom, Elsevier BV, pp. 209-213
Title Funder Award start Award end
The biology and pathogenesis of Deformed Wing Virus, the major virus pathogen of honeybees BBSRC 01 Sep 2014 31 Aug 2017
Unravelling the impact of the mite varroa destructor on the interaction between the honeybee and its viruses BBSRC 01 Jan 2011 31 Dec 2013
(IF0173) Genomic approaches for studying honeybee biology and improving bee health Department for Environment, Food and Rural Affairs 01 Feb 2009 31 Mar 2010