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Proteomics RTP Publications

Proteomics RTP Publications

2021

(1) Vu, T.; Taylor, M. J.; Singh, H.; Bilmoria, J.; Bottrill, A.; Sahota, T. Synthesis and Identification of Biologically Active Mono-Labelled FITC-Insulin Conjugate. J Fluoresc 2022. https://doi.org/10.1007/s10895-021-02867-1.

(2) Karlikowska, M.; Singh, A.; Bhatt, A.; Ott, S.; Bottrill, A. R.; Besra, G. S.; Fullam, E. Biochemical and Phenotypic Characterisation of the Mycobacterium Smegmatis Transporter UspABC. The Cell Surface 2021, 7, 100052. https://doi.org/10.1016/j.tcsw.2021.100052.

(3) Jones, R. A.; Shropshire, H.; Zhao, C.; Murphy, A.; Lidbury, I.; Wei, T.; Scanlan, D. J.; Chen, Y. Phosphorus Stress Induces the Synthesis of Novel Glycolipids in Pseudomonas Aeruginosa That Confer Protection against a Last-Resort Antibiotic. ISME J 2021, 15 (11), 3303–3314. https://doi.org/10.1038/s41396-021-01008-7.

(4) Pardal, A. J.; Bowman, A. J. Nuclear Import and Chaperoning of Monomeric Histones H3 and H4 Is Mediated by Imp5, NASP and the HAT1 Complex; bioRxiv, 2021; p 2021.10.19.464968. https://doi.org/10.1101/2021.10.19.464968.

(5) Linley, A. J.; Karydis, L. I.; Mondru, A. K.; D’Avola, A.; Shmrany, H. A.; Cicconi, S.; Griffin, R.; Forconi, F.; Pettitt, A. R.; Kalakonda, N.; Rawstron, A. C.; Hillmen, P.; Steele, A. J.; MacEwan, D. J.; Packham, G.; Prior, I. A.; Slupsky, J. R. Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells. Clin Cancer Res 2021, 27 (20), 5647–5659. https://doi.org/10.1158/1078-0432.CCR-21-0161.

(6) Rahman, A.; Lorincz, P.; Juhasz, G.; Zhang, Y.; Nezis, I. GMAP Is an Atg8a-Interacting Protein That Regulates Golgi Turnover In Drosophila; SSRN Scholarly Paper ID 3920639; Social Science Research Network: Rochester, NY, 2021. https://doi.org/10.2139/ssrn.3920639.

(7) Tinoco, A. B.; Barreiro-Iglesias, A.; Yañez Guerra, L. A.; Delroisse, J.; Zhang, Y.; Gunner, E. F.; Zampronio, C. G.; Jones, A. M.; Egertová, M.; Elphick, M. R. Ancient Role of Sulfakinin/Cholecystokinin-Type Signalling in Inhibitory Regulation of Feeding Processes Revealed in an Echinoderm. eLife 2021, 10, e65667. https://doi.org/10.7554/eLife.65667.

(8) Lidbury, I. D. E. A.; Raguideau, S.; Liu, S.; Murphy, A. R. J.; Stark, R.; Borsetto, C.; Fraser, T.; Goodall, A.; Bottrill, A.; Jones, A.; Bending, G. D.; Tibbet, M.; Hammond, J. P.; Quince, C.; Scanlan, D. J.; Pandhal, J.; Wellington, E. M. H. Meta-Exoproteomics Identifies Active Plant-Microbe Interactions Operating in the Rhizosphere; bioRxiv, 2021; p 2021.09.01.458574. https://doi.org/10.1101/2021.09.01.458574.

(9) Redkar, A.; Sabale, M.; Schudoma, C.; Zechmann, B.; Gupta, Y. K.; López-Berges, M. S.; Venturini, G.; Gimenez-Ibanez, S.; Turrà, D.; Solano, R.; Pietro, A. D. Conserved Secreted Effectors Determine Endophytic Growth and Multi-Host Plant Compatibility in a Vascular Wilt Fungus; bioRxiv, 2021; p 2021.08.29.457830. https://doi.org/10.1101/2021.08.29.457830.

(10) Hatano, T.; Palani, S.; Papatziamou, D.; Souza, D. P.; Salzer, R.; Tamarit, D.; Makwana, M.; Potter, A.; Haig, A.; Xu, W.; Townsend, D.; Rochester, D.; Bellini, D.; Hussain, H. M. A.; Ettema, T.; Löwe, J.; Baum, B.; Robinson, N. P.; Balasubramanian, M. Characterisation of the Ubiquitin-ESCRT Pathway in Asgard Archaea Sheds New Light on Origins of Membrane Trafficking in Eukaryotes; bioRxiv, 2021; p 2021.08.17.456605. https://doi.org/10.1101/2021.08.17.456605.

(11) Borsetto, C.; Raguideau, S.; Travis, E.; Kim, D.-W.; Lee, D.-H.; Bottrill, A.; Stark, R.; Song, L.; Cha, C.-J.; Pearson, J.; Quince, C.; Singer, A. C.; Wellington, E. M. H. Impact of Sulfamethoxazole on a Riverine Microbiome. Water Research 2021, 201, 117382. https://doi.org/10.1016/j.watres.2021.117382.

(12) Dwomoh, L.; Rossi, M.; Scarpa, M.; Khajehali, E.; Molloy, C.; Herzyk, P.; Mistry, S. N.; Bottrill, A. R.; Sexton, P. M.; Christopoulos, A.; Conn, P. J.; Lindsley, C. W.; Bradley, S. J.; Tobin, A. B. Activation of M1 Muscarinic Receptors Reduce Pathology and Slow Progression of Neurodegenerative Disease; bioRxiv, 2021; p 2021.07.30.454298. https://doi.org/10.1101/2021.07.30.454298.

(13) Murphy, A. R. J.; Scanlan, D. J.; Chen, Y.; Adams, N. B. P.; Cadman, W. A.; Bottrill, A.; Bending, G.; Hammond, J. P.; Hitchcock, A.; Wellington, E. M. H.; Lidbury, I. D. E. A. Transporter Characterisation Reveals Aminoethylphosphonate Mineralisation as a Key Step in the Marine Phosphorus Redox Cycle. Nat Commun 2021, 12 (1), 4554. https://doi.org/10.1038/s41467-021-24646-z.

(14) Rangama, S.; Lidbury, I. D. E. A.; Holden, J. M.; Borsetto, C.; Murphy, A. R. J.; Hawkey, P. M.; Wellington, E. M. H. Mechanisms Involved in the Active Secretion of CTX-M-15 β-Lactamase by Pathogenic Escherichia Coli ST131. Antimicrobial Agents and Chemotherapy 2021. https://doi.org/10.1128/AAC.00663-21.

(15) Larocque, G.; Moore, D. J.; Sittewelle, M.; Kuey, C.; Hetmanski, J. H. R.; La-Borde, P. J.; Wilson, B. J.; Clarke, N. I.; Caswell, P. T.; Royle, S. J. Intracellular Nanovesicles Mediate Α5β1 Integrin Trafficking during Cell Migration. Journal of Cell Biology 2021, 220 (10), e202009028. https://doi.org/10.1083/jcb.202009028.

(16) Querques, F.; Darling, S.; Cheetham-Wilkinson, I.; Kim, R. Q.; Hapangama, D. K.; Sixma, T. K.; Coulson, J. M. S18-Phosphorylation of USP7 Regulates Interaction with TCEAL4 That Defines Specific Complexes and Potentially Distinct Functions; bioRxiv, 2021; p 2021.07.07.451439. https://doi.org/10.1101/2021.07.07.451439.

(17) Vong, Y. H.; Sivashanmugam, L.; Leech, R.; Zaucker, A.; Jones, A.; Sampath, K. The RNA-Binding Protein Igf2bp3 Is Critical for Embryonic and Germline Development in Zebrafish. PLOS Genetics 2021, 17 (7), e1009667. https://doi.org/10.1371/journal.pgen.1009667.

(18) Wright, R. J.; Bosch, R.; Langille, M. G. I.; Gibson, M. I.; Christie-Oleza, J. A. A Multi-OMIC Characterisation of Biodegradation and Microbial Community Succession within the PET Plastisphere. Microbiome 2021, 9 (1), 141. https://doi.org/10.1186/s40168-021-01054-5.

(19) Durand, S.; Callan-Sidat, A.; McKeown, J.; Li, S.; Kostova, G.; Hernandez-Fernaud, J. R.; Alam, M. T.; Millard, A.; Allouche, D.; Constantinidou, C.; Condon, C.; Denham, E. L. Identification of an RNA Sponge That Controls the RoxS Riboregulator of Central Metabolism in Bacillus Subtilis. Nucleic Acids Research 2021, 49 (11), 6399–6419. https://doi.org/10.1093/nar/gkab444.

(20) Zeeshan, M.; Pandey, R.; Subudhi, A. K.; Ferguson, D. J. P.; Kaur, G.; Rashpa, R.; Nugmanova, R.; Brady, D.; Bottrill, A. R.; Vaughan, S.; Brochet, M.; Bollen, M.; Pain, A.; Holder, A. A.; Guttery, D. S.; Tewari, R. Protein Phosphatase 1 Regulates Atypical Mitotic and Meiotic Division in Plasmodium Sexual Stages. Commun Biol 2021, 4 (1), 1–14. https://doi.org/10.1038/s42003-021-02273-0.

(21) Daks, A.; Petukhov, A.; Fedorova, O.; Shuvalov, O.; Kizenko, A.; Tananykina, E.; Vasileva, E.; Semenov, O.; Bottrill, A.; Barlev, N. The RNA-Binding Protein HuR Is a Novel Target of Pirh2 E3 Ubiquitin Ligase. Cell Death Dis 2021, 12 (6), 1–14. https://doi.org/10.1038/s41419-021-03871-w.

(22) Cai, W.; Egertová, M.; Zampronio, C. G.; Jones, A. M.; Elphick, M. R. Molecular Identification and Cellular Localization of a Corticotropin-Releasing Hormone-Type Neuropeptide in an Echinoderm. NEN 2021. https://doi.org/10.1159/000517087.

(23) Aguilo-Ferretjans, M. del M.; Bosch, R.; Puxty, R. J.; Latva, M.; Zadjelovic, V.; Chhun, A.; Sousoni, D.; Polin, M.; Scanlan, D. J.; Christie-Oleza, J. A. Pili Allow Dominant Marine Cyanobacteria to Avoid Sinking and Evade Predation. Nat Commun 2021, 12 (1), 1857. https://doi.org/10.1038/s41467-021-22152-w.

(24) Helliwell, K. E.; Harrison, E. L.; Christie-Oleza, J. A.; Rees, A. P.; Kleiner, F. H.; Gaikwad, T.; Downe, J.; Aguilo-Ferretjans, M. M.; Al-Moosawi, L.; Brownlee, C.; Wheeler, G. L. A Novel Ca2+ Signaling Pathway Coordinates Environmental Phosphorus Sensing and Nitrogen Metabolism in Marine Diatoms. Current Biology 2021, 31 (5), 978-989.e4. https://doi.org/10.1016/j.cub.2020.11.073.

(25) Jacomin, A.-C.; Gohel, R.; Hussain, Z.; Varga, A.; Maruzs, T.; Eddison, M.; Sica, M.; Jain, A.; Moffat, K. G.; Johansen, T.; Jenny, A.; Juhasz, G.; Nezis, I. P. Degradation of Arouser by Endosomal Microautophagy Is Essential for Adaptation to Starvation in Drosophila. Life Science Alliance 2021, 4 (2). https://doi.org/10.26508/lsa.202000965.

(26) Durr, J.; Reyt, G.; Spaepen, S.; Hilton, S.; Meehan, C.; Qi, W.; Kamiya, T.; Flis, P.; Dickinson, H. G.; Feher, A.; Shivshankar, U.; Pavagadhi, S.; Swarup, S.; Salt, D.; Bending, G. D.; Gutierrez-Marcos, J. A Novel Signaling Pathway Required for Arabidopsis Endodermal Root Organization Shapes the Rhizosphere Microbiome. Plant and Cell Physiology 2021, 62 (2), 248–261. https://doi.org/10.1093/pcp/pcaa170.

(27) Furze, C. M.; Delso, I.; Casal, E.; Guy, C. S.; Seddon, C.; Brown, C. M.; Parker, H. L.; Radhakrishnan, A.; Pacheco-Gomez, R.; Stansfeld, P. J.; Angulo, J.; Cameron, A. D.; Fullam, E. Structural Basis of Trehalose Recognition by the Mycobacterial LpqY-SugABC Transporter. Journal of Biological Chemistry 2021, 296, 100307. https://doi.org/10.1016/j.jbc.2021.100307.

(28) Lee, Y.-S.; Maple, R.; Dürr, J.; Dawson, A.; Tamim, S.; del Genio, C.; Papareddy, R.; Luo, A.; Lamb, J. C.; Amantia, S.; Sylvester, A. W.; Birchler, J. A.; Meyers, B. C.; Nodine, M. D.; Rouster, J.; Gutierrez-Marcos, J. A Transposon Surveillance Mechanism That Safeguards Plant Male Fertility during Stress. Nat. Plants 2021, 7 (1), 34–41. https://doi.org/10.1038/s41477-020-00818-5.

(29) Shropshire, H.; Jones, R. A.; Aguilo-Ferretjans, M. M.; Scanlan, D. J.; Chen, Y. Proteomics Insights into the Burkholderia Cenocepacia Phosphorus Stress Response. Environmental Microbiology 2021, 23 (9), 5069–5086. https://doi.org/10.1111/1462-2920.15451.

(30) L. Bailey, T.; Ramon Hernandez-Fernaud, J.; I. Gibson, M. Proline Pre-Conditioning of Cell Monolayers Increases Post-Thaw Recovery and Viability by Distinct Mechanisms to Other Osmolytes. RSC Medicinal Chemistry 2021, 12 (6), 982–993. https://doi.org/10.1039/D1MD00078K.

(31) Alhujaily, M.; Abbas, H.; Xue, M.; de la Fuente, A.; Rabbani, N.; Thornalley, P. J. Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome. Frontiers in Oncology 2021, 11.

2020

(1) Linley, A. J.; Karydis, L. I.; Mondru, A.; D’Avola, A.; Cicconi, S.; Griffin, R.; Forconi, F.; Pettitt, A. R.; Kalakonda, N.; Rawstron, A.; Hillmen, P.; Steele, A. J.; MacEwan, D. J.; Packham, G.; Prior, I. A.; Slupsky, J. R. Kinobead Profiling Reveals Reprogramming of B-Cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells. bioRxiv 2020, 841312. https://doi.org/10.1101/841312.

(2) Jacomin, A.-C.; Petridi, S.; Di Monaco, M.; Bhujabal, Z.; Jain, A.; Mulakkal, N. C.; Palara, A.; Powell, E. L.; Chung, B.; Zampronio, C.; Jones, A.; Cameron, A.; Johansen, T.; Nezis, I. P. Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila. Cell Reports 2020, 31 (8), 107695. https://doi.org/10.1016/j.celrep.2020.107695.

(3) Zeeshan, M.; Pandey, R.; Ferguson, D. J. P.; Tromer, E. C.; Markus, R.; Abel, S.; Brady, D.; Daniel, E.; Limenitakis, R.; Bottrill, A. R.; Le Roch, K. G.; Holder, A. A.; Waller, R. F.; Guttery, D. S.; Tewari, R. Real-Time Dynamics of Plasmodium NDC80 Reveals Unusual Modes of Chromosome Segregation during Parasite Proliferation. J. Cell. Sci. 2020. https://doi.org/10.1242/jcs.245753.

(4) Chhun, A.; Sousoni, D.; Aguiló-Ferretjans, M. del M.; Song, L.; Corre, C.; Christie-Oleza, J. A. Phytoplankton Trigger the Production of Cryptic Metabolites in the Marine Actinobacteria Salinispora Tropica. bioRxiv 2020, 2020.05.18.103358. https://doi.org/10.1101/2020.05.18.103358.

(5) Firczuk, H.; Teahan, J.; Mendes, P.; McCarthy, J. E. G. Multisite Rate Control Analysis Identifies Ribosomal Scanning as the Sole High-Capacity/Low-Flux-Control Step in MRNA Translation. FEBS J. 2020, 287 (5), 925–940. https://doi.org/10.1111/febs.15059.

(6) Pandey, R.; Abel, S.; Boucher, M.; Wall, R. J.; Zeeshan, M.; Rea, E.; Freville, A.; Lu, X. M.; Brady, D.; Daniel, E.; Stanway, R. R.; Wheatley, S.; Batugedara, G.; Hollin, T.; Bottrill, A. R.; Gupta, D.; Holder, A. A.; Le Roch, K. G.; Tewari, R. Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell Rep 2020, 30 (6), 1883-1897.e6. https://doi.org/10.1016/j.celrep.2020.01.033.

(7) Hatano, T.; Sivashanmugam, L.; Suchenko, A.; Hussain, H.; Balasubramanian, M. K. Pick-Ya Actin – a Method to Purify Actin Isoforms with Bespoke Key Post-Translational Modifications. J Cell Sci 2020, 133 (2). https://doi.org/10.1242/jcs.241406.

(8) L. Parker, H.; F. Tomás, R. M.; M. Furze, C.; S. Guy, C.; Fullam, E. Asymmetric Trehalose Analogues to Probe Disaccharide Processing Pathways in Mycobacteria. Organic & Biomolecular Chemistry 2020, 18 (18), 3607–3612. https://doi.org/10.1039/D0OB00253D.

2019

(9) Palani, S.; Köster, D. V.; Hatano, T.; Kamnev, A.; Kanamaru, T.; Brooker, H. R.; Hernandez-Fernaud, J. R.; Jones, A. M. E.; Millar, J. B. A.; Mulvihill, D. P.; Balasubramanian, M. K. Phosphoregulation of Tropomyosin Is Crucial for Actin Cable Turnover and Division Site Placement. J Cell Biol 2019, jcb.201809089. https://doi.org/10.1083/jcb.201809089.

(10) Fenn, J. S.; Nepravishta, R.; Guy, C. S.; Harrison, J.; Angulo, J.; Cameron, A. D.; Fullam, E. Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium Tuberculosis Substrate-Binding Protein UgpB. ACS Chem. Biol. 2019, 14 (9), 1879–1887. https://doi.org/10.1021/acschembio.9b00204.

(11) Siddiqui, N.; Zwetsloot, A. J.; Bachmann, A.; Roth, D.; Hussain, H.; Brandt, J.; Kaverina, I.; Straube, A. PTPN21 and Hook3 Relieve KIF1C Autoinhibition and Activate Intracellular Transport. Nat Commun 2019, 10 (1), 1–16. https://doi.org/10.1038/s41467-019-10644-9.

(12) Pandey, R.; Abel, S.; Boucher, M.; Wall, R. J.; Zeeshan, M.; Rea, E.; Freville, A.; Lu, X. M.; Brady, D.; Daniel, E.; Stanway, R. R.; Wheatley, S.; Batugedara, G.; Hollin, T.; Bottrill, A. R.; Gupta, D.; Holder, A. A.; Roch, K. G. L.; Tewari, R. Plasmodium Condensin Core Subunits (SMC2/SMC4) Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. bioRxiv 2019, 674028. https://doi.org/10.1101/674028.

(13) Guy, C. S.; Gibson, M. I.; Fullam, E. Targeting Extracellular Glycans: Tuning Multimeric Boronic Acids for Pathogen-Selective Killing of Mycobacterium Tuberculosis. Chem. Sci. 2019, 10 (23), 5935–5942. https://doi.org/10.1039/C9SC00415G.

(14) Jacomin, A.-C.; Petridi, S.; DiMonaco, M.; Jain, A.; Bhujabal, Z.; Mulakkal, N.; Palara, A.; Powell, E. L.; Chung, B.; Zampronio, C. G.; Jones, A.; Cameron, A.; Johansen, T.; Nezis, I. P. Atg8a Interacts with Transcription Factor Sequoia to Control the Expression of Autophagy Genes in Drosophila. bioRxiv 2019, 611731. https://doi.org/10.1101/611731.

(15) Tchoupa, A. K.; Jones, R. A.; Kuroki, A.; Alam, M. T.; Perrier, S.; Chen, Y.; Unnikrishnan, M. The Type VII Secretion System Protects Staphylococcus Aureus against Antimicrobial Host Fatty Acids. bioRxiv 2019, 572172. https://doi.org/10.1101/572172.

(16) Syed, J.; Palani, S.; Clarke, S. T.; Asad, Z.; Bottrill, A. R.; Jones, A. M. E.; Sampath, K.; Balasubramanian, M. K. Expanding the Zebrafish Genetic Code through Site-Specific Introduction of Azido-Lysine, Bicyclononyne-Lysine, and Diazirine-Lysine. International Journal of Molecular Sciences 2019, 20 (10), 2577. https://doi.org/10.3390/ijms20102577.

(17) Kröber, E.; Schäfer, H. Identification of Proteins and Genes Expressed by Methylophaga Thiooxydans During Growth on Dimethylsulfide and Their Presence in Other Members of the Genus. Front. Microbiol. 2019, 10. https://doi.org/10.3389/fmicb.2019.01132.

2018

(18) Siddiqui, N.; Bachmann, A.; Zwetsloot, A. J.; Hussain, H.; Roth, D.; Kaverina, I.; Straube, A. Activation of Intracellular Transport by Relieving KIF1C Autoinhibition. bioRxiv 2018, 488049. https://doi.org/10.1101/488049.

(19) Goodman, J. K.; Zampronio, C. G.; Jones, A. M. E.; Hernandez-Fernaud, J. R. Updates of the In-Gel Digestion Method for Protein Analysis by Mass Spectrometry. Proteomics 2018, 18 (23), e1800236. https://doi.org/10.1002/pmic.201800236.

(20) Apta-Smith, M. J.; Hernandez-Fernaud, J. R.; Bowman, A. J. Evidence for the Nuclear Import of Histones H3.1 and H4 as Monomers. EMBO J. 2018, 37 (19). https://doi.org/10.15252/embj.201798714.

(21) Pilkington, E. H.; Gustafsson, O. J. R.; Xing, Y.; Hernandez-Fernaud, J.; Zampronio, C.; Kakinen, A.; Faridi, A.; Ding, F.; Wilson, P.; Ke, P. C.; Davis, T. P. Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide. ACS Nano 2018, 12 (6), 6066–6078. https://doi.org/10.1021/acsnano.8b02346.

(22) Lin, M.; Egertová, M.; Zampronio, C. G.; Jones, A. M.; Elphick, M. R. Functional Characterization of a Second Pedal Peptide/Orcokinin-Type Neuropeptide Signaling System in the Starfish Asterias Rubens. J. Comp. Neurol. 2018, 526 (5), 858–876. https://doi.org/10.1002/cne.24371.

(23) Hatano, T.; Alioto, S.; Roscioli, E.; Palani, S.; Clarke, S. T.; Kamnev, A.; Hernandez-Fernaud, J. R.; Sivashanmugam, L.; Chapa-Y-Lazo, B.; Jones, A. M. E.; Robinson, R. C.; Sampath, K.; Mishima, M.; McAinsh, A. D.; Goode, B. L.; Balasubramanian, M. K. Rapid Production of Pure Recombinant Actin Isoforms in Pichia Pastoris. J. Cell. Sci. 2018, 131 (8). https://doi.org/10.1242/jcs.213827.

(24) Kaur, A.; Hernandez-Fernaud, J. R.; Aguilo-Ferretjans, M. D. M.; Wellington, E. M.; Christie-Oleza, J. A. 100 Days of Marine Synechococcus-Ruegeria Pomeroyi Interaction: A Detailed Analysis of the Exoproteome. Environ. Microbiol. 2018, 20 (2), 785–799. https://doi.org/10.1111/1462-2920.14012.

(25) Cai, W.; Kim, C.-H.; Go, H.-J.; Egertová, M.; Zampronio, C. G.; Jones, A. M.; Park, N. G.; Elphick, M. R. Biochemical, Anatomical, and Pharmacological Characterization of Calcitonin-Type Neuropeptides in Starfish: Discovery of an Ancient Role as Muscle Relaxants. Front Neurosci 2018, 12, 382. https://doi.org/10.3389/fnins.2018.00382.

2017

(26) Lin, M.; Egertová, M.; Zampronio, C. G.; Jones, A. M.; Elphick, M. R. Pedal Peptide/Orcokinin-Type Neuropeptide Signaling in a Deuterostome: The Anatomy and Pharmacology of Starfish Myorelaxant Peptide in Asterias Rubens. J. Comp. Neurol. 2017, 525 (18), 3890–3917. https://doi.org/10.1002/cne.24309.

(27) Tyrakis, P. A.; Yurkovich, M. E.; Sciacovelli, M.; Papachristou, E. K.; Bridges, H. R.; Gaude, E.; Schreiner, A.; D’Santos, C.; Hirst, J.; Hernandez-Fernaud, J.; Springett, R.; Griffiths, J. R.; Frezza, C. Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects. Cell Rep 2017, 21 (4), 1036–1047. https://doi.org/10.1016/j.celrep.2017.09.092.

(28) Narvaez, A. J.; Ber, S.; Crooks, A.; Emery, A.; Hardwick, B.; Guarino Almeida, E.; Huggins, D. J.; Perera, D.; Roberts-Thomson, M.; Azzarelli, R.; Hood, F. E.; Prior, I. A.; Walker, D. W.; Boyce, R.; Boyle, R. G.; Barker, S. P.; Torrance, C. J.; McKenzie, G. J.; Venkitaraman, A. R. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol 2017, 24 (8), 1017-1028.e7. https://doi.org/10.1016/j.chembiol.2017.07.009.

(29) Christie-Oleza, J. A.; Sousoni, D.; Lloyd, M.; Armengaud, J.; Scanlan, D. J. Nutrient Recycling Facilitates Long-Term Stability of Marine Microbial Phototroph-Heterotroph Interactions. Nat Microbiol 2017, 2, 17100. https://doi.org/10.1038/nmicrobiol.2017.100.

(30) Lin, M.; Mita, M.; Egertová, M.; Zampronio, C. G.; Jones, A. M.; Elphick, M. R. Cellular Localization of Relaxin-like Gonad-Stimulating Peptide Expression in Asterias Rubens: New Insights into Neurohormonal Control of Spawning in Starfish. J. Comp. Neurol. 2017, 525 (7), 1599–1617. https://doi.org/10.1002/cne.24141.

(31) Lidbury, I. D. E. A.; Fraser, T.; Murphy, A. R. J.; Scanlan, D. J.; Bending, G. D.; Jones, A. M. E.; Moore, J. D.; Goodall, A.; Tibbett, M.; Hammond, J. P.; Wellington, E. M. H. The “known” Genetic Potential for Microbial Communities to Degrade Organic Phosphorus Is Reduced in Low-PH Soils. Microbiologyopen 2017, 6 (4). https://doi.org/10.1002/mbo3.474.

(32) Lidbury, I. D. E. A.; Murphy, A. R. J.; Fraser, T. D.; Bending, G. D.; Jones, A. M. E.; Moore, J. D.; Goodall, A.; Tibbett, M.; Hammond, J. P.; Scanlan, D. J.; Wellington, E. M. H. Identification of Extracellular Glycerophosphodiesterases in Pseudomonas and Their Role in Soil Organic Phosphorus Remineralisation. Sci Rep 2017, 7 (1), 2179. https://doi.org/10.1038/s41598-017-02327-6.

2016

(33) Üstün, S.; Sheikh, A.; Gimenez-Ibanez, S.; Jones, A.; Ntoukakis, V.; Börnke, F. The Proteasome Acts as a Hub for Plant Immunity and Is Targeted by Pseudomonas Type III Effectors. Plant Physiol. 2016, 172 (3), 1941–1958. https://doi.org/10.1104/pp.16.00808.

(34) Lidbury, I. D. E. A.; Murphy, A. R. J.; Scanlan, D. J.; Bending, G. D.; Jones, A. M. E.; Moore, J. D.; Goodall, A.; Hammond, J. P.; Wellington, E. M. H. Comparative Genomic, Proteomic and Exoproteomic Analyses of Three Pseudomonas Strains Reveals Novel Insights into the Phosphorus Scavenging Capabilities of Soil Bacteria. Environ. Microbiol. 2016, 18 (10), 3535–3549. https://doi.org/10.1111/1462-2920.13390.

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Lab C115,
School of Life Sciences,
Gibbet Hill Road,
University of Warwick,
CV4 7AL

Tel: 024 7615 0439
proteomics@warwick.ac.uk


People

Alex Jones (Director)

Andrew Bottrill (Manager)

Cleidi Zampronio (Senior Technician)


Learn More

(PDF Document) What we do (Flyer)

(PDF Document) What we do (Poster)

(PDF Document) Proteomics Concepts Poster


Training

University of Warwick users can learn more about the service, and undertake training modules via the Proteomics Moodle


"How to?" Video Guides

Video Introduction to the lab

Video protocol: Gel Digest

Video protocol: In Solution Digest

Video protocol: Stage Tip


Reading Resources

Essential background reading for those wanting a deeper understanding of Proteomics and Mass Spectrometry (library subscriptions required):

Proteomics: Methods and Protocols

Mass Spectrometry Data Analysis in Proteomics

Introduction to Proteomics: Principles and Applications

Mass Spectrometry: a Text Book