Our Research
Our lab is developing new technologies (computational and experimental) for the de novo engineering of biomolecules and their interactions (in particular, with the long-term goal of creating synthetic phages as antimicrobials).
De novo engineering of biological circuits through in silico evolution
We developed a new strategy for a novel generation of synthetic regulatory networks relying on RNA instead of proteins as it occurs with conventional gene networks. Synthetic RNA molecules detect a small-molecule and transduce the signal into other RNA molecules which could be cascaded and/or combined through RNA-only pathways to finally control the expression of targeted proteins.