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The Vision

The therapeutics of tomorrow will be individualized, specific, and self-regulated. This could be achieved by synthetic organisms, once we know how to engineer them. The simplest and safest is the bacteriophage. I believe that by engineering a synthetic phage to be used in phage therapy against antibiotic-resistant bacteria, my lab will provide a proof-of-concept that will trigger more synthetic biology efforts to fight human diseases. For this, we work at the interface of molecular biology, combinatorial optimization, microfluidics, directed evolution and 3D printing.

phageAlfonso pipetting