School of Life Sciences
Tel: +44(0)24 7657 5864
The discovery of antibiotics in the 20th century revolutionized modern medicine. However, their widespread and persistent use as both prophylaxis and therapeutics has resulted in the emergence of antimicrobial resistance (AMR) across numerous bacterial genera. Antibiotic agents enter the environment via a variety of anthropogenic sources including wastewater treatment plants and agricultural runoff . There are still significant uncertainties about the whole waste treatment process particularly surrounding human and animal faeces where the gut microbial resistome may be significant.
The aim of this PhD is to further elucidate dissemination pathways for antimicrobial resistance genes (ARGs) via waste water treatment plants, hospital and animal waste. An evaluation of the impact of hospital effluent on the supply of ARGs to the waste water treatment plant and evaluate the efficiency of waste water treatment plant in reducing the antimicrobial resistance load will be done. In addition, further investigation will be carried out to determine the contribution of animal manure to environmental reservoirs of ARG and whether anaerobic digestion can mitigate the spread of resistance to the environment.