Welcome to my website in University of Warwick!
I’m Song Feng, a Chinese climber studying in United Kingdom. I am currently a PhD student in School of Life Science, University of Warwick, under supervision of Prof. Orkun Soyer.
Generally, I am interested in complex systems and evolution theory. My current focus is evolutionary systems and synthetic biology, particularly about cellular networks.
Particularly, my PhD project is about "Exploring design principles of cellular information processing and decision making via evolution in silico". By collaborating with Prof. Peter Swain and Dr. Julien Ollivier, we managed to build up a program, called BioJazz, to combine evolutionary algorithm with rule-based modelling approach (see ANC). We used this program to evolve a well-known cellular decision making dynamics, ultrasensitivity, we found that besides allosteric regulation and zero-order ultrasensitivity, enzyme sequestration can be an evolutionary design principle for protein interaction networks to generate diverse response dynamics. Meanwhile, we discovered that bistable dynamics readily emerged from evolution of ultrasensitivity, we successfully identified the smallest bistable motif which requires only one kinase with two distinct conformation states and one substrate with autodephosphorylation reaction after dissecting the complex evolved networks. This lead us to explore the design principle for bistable signaling networks. We are currently collaborating with serious mathematicians Dr Elisenda Feliu and Prof. Carsten Wiuf to both study the stochacity in the bistable motif and also search the so-called sufficient conditions for bistable biochemical reaction network.
If you want to find more, please refer to my resume.
School of Life Sciences, University of Warwick,
Coventry, CV4 7AL, United Kingdom
Song Feng (馮淞)
OSS lab, School of Life Sciences, University of Warwick, Coventry CV47AL, United Kingdom
Song dot Feng at warwick dot ac dot uk