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Hadi Putra

A doctoral student at School of Life Sciences, the University of Warwick. My experiment is focusing on the environmental epigenome. I have my B.Sc. (Hons) in Biotechnology from Universiti Malaysia Sabah, where I did my final year project in the analysis of microRNAs expression across different stages of pineapple fruit maturation. I am also a former intern at First BASE Laboratories Sdn Bhd (Malaysia) and Quality Control Supervisor from PT Karunia Alam Segar (Wings Group, Indonesia).

Project Title: Stress-Induced Epigenetic Inheritance in Plants

Doctoral Research

Plants are a sessile organism which makes them more susceptible towards different types of environmental stress (salinity, temperature, pest, drought etc.). Exposure to stress can lead to cell apoptosis and also plant necrosis. Thus plants need efficient short-term strategies to adapt to environmental stress. These strategies include changes in DNA methylation and histone modification. It has been well documented that the epigenetic information encoded as DNA methylation can be transmitted through several generations. However, in the absence of stress, the epigenetic changes are erased and rapidly reprogrammed. This epigenetic reprogramming usually occurs during gametogenesis and after fertilization, and it is likely that plants that are propagated through somatic regeneration contain epigenetic changes that are stably maintained in successive generations. Thus I postulated that stress induces during the somatic embryogenesis will be stable in successive generations of regenerated plants.
My research findings indicated that the introduction of stress during somatic embryogenesis enable plants to develop transgenerational adaptation to the non-stress second generation plants. These changes were also followed by changes in transcriptome and methylome.

Other Interests

Beside epigenetics, I have research interests in the topics of microRNAs. Other than plants, I also interested to work in biomedical research, especially in oncology.


• Wibowo, A., Becker, C., Marconi, G., Durr, J., Price, J., Hagman, J., Papareddy, R., Putra, H., Kageyama, J., Becker, J., Weigel, D., and Gutierrez-Marcos, J. (2016). Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity. eLife, 5, e13546.
• Wibowo, A., Becker, C., Durr, J., Spaepen, S., Hilton, S., Putra, H., … Gutierrez-Marcos, J. (2018). Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction lead to stable phenotypic variation in plants. (submitted to PNAS)
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School of Life Sciences
The University of Warwick
Gibbet Hill Campus
United Kingdom

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