Hello, I’m Sarah, a final year PhD student in the School of Life Sciences here at the University of Warwick.
4-year (Oct 2011 - Oct 2015) BBSRC funding for a full-time PhD with Professor Colin Robinson working on the Twin-arginine Translocase (Tat).
My time at Warwick so far:
Oct 2011 - July 2012: Completion of the BBSRC 9-month training period
During this time I completed 2 mini-projects:
Jan – Mar 2012: this project aimed to gain structural insight into the Gram-positive TatAyCy complex from Bacillus subtilis via the use of electron microscopy (see My Research section).
Apr – Jun 2012: this project focused on optimising the co-expression and co–purification of MurL and CobQ – a potential amidase that is implicated in the synthesis of the peptidoglycan cell wall of Gram-positive and –negative bacteria. The continued misuse of antibiotics has led to a drastic rise in antibiotic resistance amongst humans. The call for the development of new antimicrobial compounds, through the identification of novel targets, is greater than ever. The aforementioned MurL:CobQ amidase is one such target. Gaining insight into the mechanism of action of this amidase has the potential to aid the design of new antibiotics.
July 2012 - present: full-time research on Tat
August/September 2013: Commencing my CASE studentship. During this time I will be working off-site at an industrial partner, the National Institute of Biological Standards and Control (NIBSC), alongside JEOL UK (see My Research section).