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Nitha Charles Mulakkal

I am a Ph.D. student in the School of Life Sciences, working under the supervision of Dr. Ioannis Nezis. My Ph.D. is funded by the School of Life Sciences.


My Research

My research is focused on understanding the molecular mechanisms of autophagy. Autophagy is a conserved lysosome-mediated degradation pathway. The process involves transportation of a wide range of cellular substrate (protein aggregates, microorganisms and unwanted organelles) in a double membrane vesicle, called autophagosome to the lysosome for degradation. Autophagy mediates both selective and non-selective degradation.
Defects in autophagy have been implicated in many human diseases. A better understanding of the molecular mechanisms of autophagy is essential for effectively targeting this pathway for therapeutic purposes. I am using Drosophila melanogaster as a model organism to identify novel genes and processes associated with autophagy regulation especially selective autophagy.

Background

  • Master of Science: Biomedical and Molecular Science Research, 
King’s College London, U.K.
  • Bachelor of Science: Biotechnology, Kerala University, India.

Publications

  • Nitha C. Mulakkal, Peter Nagy, Szabolcs Takats, Radu Tusco, Gábor Juhász, and Ioannis P. Nezis. Autophagy in Drosophila: From Historical Studies to Current Knowledge. BioMed Research International, vol. 2014, Article ID 273473, 24 pages, 2014. doi:10.1155/2014/273473
  • Kalvari I, Tsompanis S, Mulakkal NC, Osgood R, Johansen T, Nezis IP, Promponas VJ. iLIR: A web resource for prediction of Atg8-family interacting proteins. Autophagy. 2014 Feb 26;10(5). [Epub ahead of print] PubMed PMID: 24589857.

Key conferences and symposiums

  • Presented a part of my PhD research as a talk at Warwick-Monash Alliance on Autophagy research, University of Monash, Australia, September 2015.
  • Presented a part of my PhD research as a talk at School of Life Sciences graduate symposium, University of Warwick, March 2015
  • Presented a part of my PhD research as a poster at First U.K Autophagy Network Meeting, University of Warwick, United Kingdom, May 2015.
  • Presented a part of my PhD research as a poster at Joint spring Meeting of British society of cell biology and development biology, University of Warwick, United Kingdom, April 2015.
  • Presented a part of my PhD research as a poster at Alzheimer's research UK Midlands Networking Meeting, University of Warwick, United Kingdom, April 2015.
  • Presented my MSc research as a talk at MSc research symposium, King’s college London, United Kingdom.

Key Workshops

  • One-day course on Introduction to ImageJ/Fiji at the University of Leicester, July 2015.
  • Two-day course on Quantitative Proteomics and Data Analysis at the Queens Hotel, Chester April 2016, organised by Biochemical Society.
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Nitha Charles Mulakkal

N dot C dot Mulakkal at warwick dot ac dot uk