For my PhD, under the supervision of Bridget Penman, Lorenzo Pellis and Matt Keeling, I am researching evolution of the major histocompatibilty complex (MHC). Right now I am working on two specific projects
1) Understanding how MHC haplotypes evolve, specifically looking at how duplicated MHC loci evolve
2) Understanding how pathogen strain dynamics affect which MHC genotypes (known as HLA genotypes in humans) are protective against which diseases.
I have been developing agent based models and ODE models to tackle these questions.
White C, Pellis L, Keeling M and Penman B. Detecting HLA-infectious disease associations for multi-strain pathogens, Infect Genet Evol 2020, 83:104344
Leng T, White C, Hilton J et al. The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study [version 1; peer review: 1 approved]. Wellcome Open Res 2020, 5:213
Calculation of the Maximum Threshold Cost for PCV13
Worked as a research associate with Matt Keeling and Stavros Petrou. This work was funded by and involved working with the UK Department of Health.
We simulated an individual based model for the pneumococcal disease in England and Wales and forward predict the number of cases when using and not using PCV13. Using the difference in cases allowed us to estimate a maximum threshold cost for PCV13.
Masters dissertation for my MPhys Physics with Theoretical Physics (2014), Supervisor Tobias Galla - Chaotic Dynamics in Game theory
We applied the experience weighted attraction model to many classic game theory games. We showed increasing the number of players and the number of stratergies lead to more chaotic dynamics.
Summer student report for my CERN summer student internship (2013), Supervisor Jan Fiete Grosse-Oetringhaus - Two-particle correlations in pp collisions at the LHC with ALICE
Analysed pp collision data from the LHC ALICE experiment. We look at the angles of the yielded particles from a collision and compare the differences between pp collisions and p-Pb collisions.
MSc Mathematics of Systems – University of Warwick - (2016-2017)
Mphys Physics with Theoretical Physics – University of Macnhester – (2010-2014)
Conferences, Summer Schools, Workshops
- Presented at European Conference on Mathematical and Theoretical Biology 2018
- Introduction to Machine Learning Summer School (University of Warwick, June 2017)
- CERN summer student (CERN Geneva, summer of 2013)
Office: D2.11 (Zeeman Building)