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Seminar: Optogenetic dissection of sleep circuits and functions, Professor Antoine Adamantidis, Department of Neurology, University of Bern, Switzerland

Location: MBU (A1.51), Warwick Medical School

Abstract: The functions of sleep are still a matter of debate and may include memory consolidation, brain clearance, anabolism and plasticity. Successive sleep-wake cycles rely on an appropriate balance between sleep-promoting nuclei of the brain located in the anterior hypothalamus and, arousal-promoting nuclei from the posterior hypothalamus and the brainstem. This lecture will present our characterisation of the hypothalamic modulation of brain structures including thalamic nuclei during wakefulness and sleep using optogenetics in combination with high-density electrophysiology in freely-behaving mice, as well as more recent data supporting a dual role for centro-medial thalamus in the propagation and modulation of cortical sleep slow waves and the role of media-dorsal thalamus in sleep recovery.

Biography: Antoine Adamantidis joined the Inselspital Bern as Assistant Professor in December 2013. After a PhD in molecular, cellular and behavioural Neurobiology at the University of Liege (Belgium), he worked as post doctoral fellow and successively as research associate at the Stanford University (USA). From Stanford he moved to McGill University & Douglas Mental Health University Research Institute (Canada), where he has been assistant and then adjunct professor. Professor Adamantidis serves on the editorial boards of numerous journals and he is involved as grant reviewer for many institutions. He was recipient of several awards in USA, Canada and Europe, last (2013) of the R. Broughton Young Investigator Award from the Canadian Sleep Society. He presented his research at several international congresses and seminars as invited speaker. Antoine Adamantidis is investigating the functional wiring and dynamics of neural circuits controlling sleep and wake states. He is using a combination of state-of-the-art molecular, cellular and behavioural technologies, which include genetic mouse engineering, in vitro and in vivo electrophysiology, behavioural paradigms and the emerging field of optogenetics. His research findings may lead to a better understanding of how the brain controls sleep, attention and cognition. This may open new therapeutic strategies for the treatment of sleep disorders and neuropsychiatric illnesses associated with sleep disturbances.

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