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Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction

Much of our knowledge about how T. cruzi causes Chagas disease comes from studies of infections in mice, but the data do not capture the full range of clinical outcomes seen in humans. In this paper, we developed a hamster model of T. cruzi infection with two striking features – almost exclusive restriction of chronic infection to a skin tissue niche and a progressive gait dysfunction resembling cerebral palsy.
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Wed 10 Jul 2024, 08:28 | Tags: BMS BMS_newpub