We used high-throughput single-cell RNA sequencing to reconstruct the decidual pathway in human endometrium in vitro and in vivo. This work has revealed a novel mechanism of breakdown of the feto-maternal interface in pregnancy and identified endometrial biomarkers which can be used to assess the risk of miscarriage prior to conception.
Lucas, Vrljicak et al., Communications Biology 2020, https://rdcu.be/b0zvm