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Impact of the protein corona on nanoparticles

The Gibsongroup are developing nanoparticles for biosensing, diagnostics, and delivery applications. A key challenge is how particles perform in ‘perfect’ conditions verses ‘real world’ when proteins found in blood can ’stick’ to the surface and compromise performance.

In their latest paper they show how nano-rods, with glycans on their surface, do indeed get ‘fouled’ by proteins, but show how this does not prevent their use in biosensing, and that in fact the release of serum proteins can be used to generate signal.

Read the paper here

Mon 14 Jun 2021, 18:05 | Tags: BMS