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ATP-controlled remodeling in reconstituted actomyosin

This work was conducted by Sedigheh (Mobi) Ghanbarzadeh and Darius Koester in close collaboration with collaboration with theorists Sami Al-Izzi and Richard Morris from the School of Physics, UNSW Sydney (both alumni of Warwick) and discusses how different levels of ATP (our loved fuel for molecular motors and other cellular processes) can lead to different dynamics and patterns of force generation by membrane tethered actomyosin networks. Inspired by experimental observations, we developed a new way of using a hydrodynamics approach to describe a hierarchical system of membrane tethered actin networks with a layer of force generating myosin motors atop that interact with each other while taking into account how myosin motor activity and affinity to actin depends on ATP concentrations. Read the paper here.Link opens in a new window

Fri 28 Feb 2025, 15:17 | Tags: BMS BMS_newpub