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Warwick Medical School and their Computational and Advanced Microscopy Development Unit (CAMDU) had a double success at the 25 ALERT call of the Biotechnology and Biological Sciences Research Council (BBSRC).

A cross-departmental team led by CAMDU microscopy specialist Dr. Maelle Lorvellec and Prof. Karuna Sampath (WMS) were successful with their bid and were awarded ~£370,000 for an in situ spatial transcriptomics system. This platform will allow spatially resolved gene expression profiling by imaging at subcellular resolution and high throughput (100s to 1000s of genes at a time), in a range of plant, microbe and animal models used by groups in the School of Life Sciences and WMS. The platform will complement and extend the current capabilities at Warwick for in-depth, spatially resolved analysis of biological gene expression profiles during normal development and physiology through the life course and will enable discovery of fundamental mechanisms, insights into the rules of life, and an integrated understanding of health.

Microscope specialist Dr. David Corcoran (CAMDU) together with Assistant Prof. Dr. Falk Schneider and Associate Professor Dr. Darius Köster (both WMS) and colleagues obtained ~£950,000 with their bid to install a cross-scale imaging platform that combines super-resolution with deep tissue imaging and advanced fluorescence spectroscopy. This instrument combines stimulated emission depletion (STED) super-resolution imaging with adaptive optics, fluorescence lifetime imaging (FLIM) and fluorescence correlation spectroscopy (FCS). It is uniquely suited to produce new quantitative insights by measuring absolute concentration, mobility, and binding kinetics in live samples across scales ranging from single cells up to complex tissues and model organisms. These new abilities will complement and boost our capabilities to gain new and important mechanistic understanding of biological systems from molecules and cells to entire organisms.