Our research programme in Cell and Developmental Biology is exploring the cellular basis of disease, the mechanisms that enable cell duplication, movement and repair and the self-organisational events that produce multi-cellular organisms. Our investigators also form the core of the Centre for Mechanochemical Cell Biology.
BMS Seminar: Complex waves on the surface of live cells: A new pattern formation paradigm, Professor Andrew Goryachev, Professor of Computational Cell Biology, University of Edinburgh
BMS social event
BMS Seminar: Visualising chromatin replication one molecule at a time, Dr Hasan Yardimci, The Francis Crick Institute
Using amino acids to control ice growth
The GibsonGroup, in collaboration with the Sosso Group (chemistry) are investigating how small molecules can inhibit ice recrystallisation - a property more commonly associated with macromolecules, such as ice binding proteins or some polymers. The challenge of the macromolecules is that sequential modification is challenging, and hence structure-property relationships are often missing. Here the team show that phenyl alanine can inhibit ice recrystallisation and that modulation of the hydrophobic face impacts the magnitude of the activity. This work shows that ’small molecule’ approaches can be taken to probe the complex ice/water interface, with the long term goal of finding new molecules to control ice growth.
Read the paper here.
Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes
Cancer origin identified through cell ‘surgery’
The zebra fish is a tropical fish that shares 70% of its DNA with humans. This makes it very useful to study to help us understand some human diseases. Dr Karuna Sampath tells us more.