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Biomedical Sciences

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Our research programme in Cell and Developmental Biology is exploring the cellular basis of disease, the mechanisms that enable cell duplication, movement and repair and the self-organisational events that produce multi-cellular organisms. Our investigators also form the core of the Centre for Mechanochemical Cell Biology.

Biomedical Sciences News

Using amino acids to control ice growth

The GibsonGroup, in collaboration with the Sosso Group (chemistry) are investigating how small molecules can inhibit ice recrystallisation - a property more commonly associated with macromolecules, such as ice binding proteins or some polymers. The challenge of the macromolecules is that sequential modification is challenging, and hence structure-property relationships are often missing. Here the team show that phenyl alanine can inhibit ice recrystallisation and that modulation of the hydrophobic face impacts the magnitude of the activity. This work shows that ’small molecule’ approaches can be taken to probe the complex ice/water interface, with the long term goal of finding new molecules to control ice growth.

Read the paper here.

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The zebra fish is a tropical fish that shares 70% of its DNA with humans. This makes it very useful to study to help us understand some human diseases. Dr Karuna Sampath tells us more.