New research article in Scientific Reports on circadian Pgp expression and its importance for drug transporters
Co-lead author Swati A. Kumar in a collaboration with Annabelle Ballesta, Alper Okyar, Francis Lévi, Enza Piccolo and us entitled: Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling, we described how time-of-day of drug adminstration might lead to different pharmacokinetic profiles in male and female mice.
Alper Okyar, Swati Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta, Scientific Reports, 2019, DOI: 10.1038/s41598-019-46977-0
At the graduation ceremony of the Lessing Gymnasium Uelzen, Germany, Robert argued for later school start times for teenagers, which was unfortunately overlooked by the local newspaper when covering the event.
A very warm welcome to Warwick undergraduate students Inbar and Rachael who managed to secure funding from the URSS and QBP summer schools, respectively, to the lab for their summer projects on circadian clocks.
New Imaging Equipment
Thanks to the crucial contribution of donations to the Warwick Cancer Centre, we now have been able to acquire a PhotonImager Optima for imaging at Warwick! Exquisite bioluminescence and fluorescence imaging is supported.
If you want to know what circadian phase a tissue has, but your patient is only willing to get biopsied once and not 6 times in 24 hours: Use TimeTeller