New research article in Scientific Reports on circadian Pgp expression and its importance for drug transporters
Co-lead author Swati A. Kumar in a collaboration with Annabelle Ballesta, Alper Okyar, Francis Lévi, Enza Piccolo and us entitled: Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling, we described how time-of-day of drug adminstration might lead to different pharmacokinetic profiles in male and female mice.
Alper Okyar, Swati Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta, Scientific Reports, 2019, DOI: 10.1038/s41598-019-46977-0
If you want to know what circadian phase a tissue has, but your patient is only willing to get biopsied once and not 6 times in 24 hours: Use TimeTeller
Cellular ATP levels are modulated by the circadian clock influencing mitochondrial network dynamics through DRP1 phosphorylation.
Happy to have contributed to this study from Chris Pryce's lab at the University of Zurich.