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Recent Developments in the Patho-Physiological Molecular Clocks Lab

New research article in Scientific Reports on circadian Pgp expression and its importance for drug transporters

Co-lead author Swati A. Kumar in a collaboration with Annabelle Ballesta, Alper Okyar, Francis Lévi, Enza Piccolo and us entitled: Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling, we described how time-of-day of drug adminstration might lead to different pharmacokinetic profiles in male and female mice.

Alper Okyar, Swati Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta, Scientific Reports, 2019, DOI: 10.1038/s41598-019-46977-0

Fri 19 Jul 2019, 09:00 | Tags: Publication, Circadian, 2019

Denise Vlachou's TimeTeller is out!

If you want to know what circadian phase a tissue has, but your patient is only willing to get biopsied once and not 6 times in 24 hours: Use TimeTeller

Fri 03 May 2019, 16:16 | Tags: Publication, Circadian, 2019

New paper on circadian dynamics of mitochondria and energy metabolism

Cellular ATP levels are modulated by the circadian clock influencing mitochondrial network dynamics through DRP1 phosphorylation.

Tue 27 Feb 2018, 20:38 | Tags: Publication, Circadian

New paper on the effects of chronic stress on the immune system and dopamine function

Happy to have contributed to this study from Chris Pryce's lab at the University of Zurich.

Tue 06 Feb 2018, 09:12 | Tags: Publication, 2018