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Recent Developments in the Patho-Physiological Molecular Clocks Lab

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Good Luck Rachael!

MBio student Rachael has achieved a first in her degree and has been accepted a stipend to start on the MRC DTP in IBR in September. Well done Rachael and have fun in the next four years at Warwick!

Mon 26 Jul 2021, 11:31 | Tags: 2021, Circadian, Student, MBio

New URSS and MSc students in the lab!

Two new students have joined the lab for projects over the summer.

Daniel Fox, 2nd year medical student at Warwick, has received competitive URSS funding as well as BSN project funding to conduct a project on the circadian regulation of the blood brain barrier in a mammalian in vitro model.

Vadim Vasilyev, MSc in Interdisciplinary Biomedical Research, will work on establishing a TimeTeller model for in vitro tumour models.

Welcome to both!

Tue 20 Jul 2021, 19:01 | Tags: MSc, MRCDTP, URSS

Chronotherapy: Counting down cancer

Medical News Today spoke with Robert for their “what’s exciting the experts” series. Asked what recent advances have given them the most hope and is most exciting, the obvious answer is Chronotherapy.

Mon 07 Jun 2021, 21:17 | Tags: 2021, Chronotherapy, News, Outreach

Frequency of the PROMs

PROMS

In a collaboration led by Pasquale Innominato, we evaluate the impact of different frequencies for the evaluation of patient-reported outcomes (PRO) in cancer. PRO have proven relevant positive clinical impact on patients’ communication with healthcare professionals, decision-making for management, wellbeing and overall survival. However, the optimal frequency of PRO assessment has yet to be defined. Based on the assumption that more frequent sampling would enhance accuracy, we aimed at identifying the optimal sampling frequency that does not miss clinically relevant insight.
Our analysis suggests that in patients receiving chemotherapy for advanced cancer, increasing the density of PRO collection enhances the accuracy of PRO assessment to a clinically meaningful extent. This is valid for both computation of averages symptom burden and for the recognition of episodes of severe symptom intensity.
Thu 06 May 2021, 10:10 | Tags: Publication, 2021

Coffee anyone?

coffee

Most organisms with a nervous system have been shown to sleep. Why is not yet clear, but it is clear that the longer an organism stays awake the higher the need for sleep, ie. sleep pressure.

However, the biological clock, also present in virtually all organisms, is modulating sleep need, eg. in people after a night without sleep, sleep pressure is (temporarily) reduced around sunrise courtesy of their circadian drive to become active at that time. Thus, sleep pressure and circadian rhythms influence each other.

 

Interestingly, caffeine, which is found in coffee and energy drinks promising wings, and one of the world’s most widely consumed psychoactive substances, is reducing sleep pressure by a known mechanism, but also impacting on the circadian clock. So far, the regulatory mechanisms for the interaction are at least partly unclear. 

 

In this publication, we showed how adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light on the clock, providing a molecular link between sleep pressure and circadian rhythms. These insights have implications for therapeutic strategies for rhythm disorders. 

Thu 15 Apr 2021, 14:50 | Tags: Publication, 2021

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