Our research programme in Microbiology and Infection encompasses a spectrum of research that runs from the fundamental science of model organisms to translational research on human and animal pathogens. We exploit cutting-edge high-throughput approaches, including robotics, genomics, metagenomics, bioinformatics and rapid virulence assays to link basic science to clinical applications.
We used high-throughput single-cell RNA sequencing to reconstruct the decidual pathway in human endometrium in vitro and in vivo. This work has revealed a novel mechanism of breakdown of the feto-maternal interface in pregnancy and identified endometrial biomarkers which can be used to assess the risk of miscarriage prior to conception.
Lucas, Vrljicak et al., Communications Biology 2020, https://rdcu.be/b0zvm
Senior Cancer Research UK Fellow Steve Royle tells us about his team's work looking at cell division and their research that could help develop cures for diseases including cancer.