Our research programme in Microbiology and Infection encompasses a spectrum of research that runs from the fundamental science of model organisms to translational research on human and animal pathogens. We exploit cutting-edge high-throughput approaches, including robotics, genomics, metagenomics, bioinformatics and rapid virulence assays to link basic science to clinical applications.
The influence of extrachromosomal elements in the anthrax "cross-over" strain Bacillus cereus G9241
We have now published back to back two papers on the so called anthrax “cross over strain Bacillus cereus G9241. The first paper (From cereus to anthrax and back again: The role of the PlcR regulator in the “cross-over” strain Bacillus cereus G9241) has already been highlighted. This current paper is titled, “The influence of extrachromosomal elements in the anthrax “cross-over” strain Bacillus cereus G9241.”
The work investigates the contribution of anthrax-like plasmids and a lysogenic phagemid to the pathogenic potential of the normally relatively harmless Bacillus cereus. We investigated the role of temperature and carriage of the pBCXO1 plasmid (which is homologous to the pXO1 anthrax toxin plasmid) in regulation of chromosomal genes, heavily affecting metabolism. In addition we have shown that sporulation of G9241 is very rapid at 37’C, which is characteristic of B. anthracis but unlike the ancestral B. cereus strains. Finally we isolated phagemid virions which are produced at 37’C and visualised them with electron microscopy.
Read the paper here.
From cereus to anthrax and back again: The role of the PlcR regulator in the “cross-over” strain Bacillus cereus G9241
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
Senior Cancer Research UK Fellow Steve Royle tells us about his team's work looking at cell division and their research that could help develop cures for diseases including cancer.