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Ed Galyov

Wednesday 23 November 2016 - The impact of phages on seasonality of melioidosis.

Melioidosis, a serious environmentally-acquired bacterial infection, is often characterised by a noticeable seasonality. Burkholderia pseudomallei, the causative agent of melioidosis, is commonly found in tropical soil and stagnant waters, which represent environmental reservoir of the disease. Environmental populations of B. pseudomallei are known to be regulated by a variety of biotic and abiotic factors, but the contribution of different factors to the seasonal dynamics of B. pseudomallei population is poorly understood. In this work, we studied environmental phages capable of infecting B. pseudomallei. A particular clade of phages - which is highly abundant in the endemic area of Thailand - infects B. pseudomallei according to temperature conditions: phages are predominantly lytic at a higher temperature of 37oC and mainly lysogenic at 25oC. The potential impact of these phages on the daily and seasonal dynamics of the size and composition of B. pseudomallei population was assessed using mathematical modelling. Modelling outcomes appear to correlate with the apparent higher risk of melioidosis acquisition during the “warm and wet” season.


Name: Edouard E. Galyov
Current post (since Oct 2007): Reader (Associate Professor)
University of Leicester - Department of Infection, Immunity and Inflammation

BSc, MSc. (Chemistry), 1985, Leningrad (St. Petersburg) University, Russia
PhD. (Molecular Biology), 1990, Institute of Molecular Biology, Russian Acad. Sci., Moscow, Russia
History of employment:
1995-2007 Institute for Animal Health, Compton, UK. Senior Research Scientist
1991-1995 Postdoctoral scientist, University of Umeå, Sweden.
1986-1990 Ph.D. student, Institute of Molecular Biology, Russian Acad. Sci., Moscow, and Inst. of Immunology, Lubuchany, Russia