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Dr Naila Rabbani graduated with a BSc in Biological and Medicinal Chemistry in 1998 and PhD in Disease Mechanisms and Therapeutics in 2001 at the University of Essex, Colchester, U.K. She pursued pre-doctoral research improving analytical methods to identify and quantify markers of protein damage by glycation and has maintained an interest in protein glycation in disease mechanisms and therapeutics. She was awarded a British Heart Foundation Intermediate Fellowship in 2006 for research on glycation of lipoproteins and became an assistant Professor in Experimental Systems Biology at the University of Warwick in 2007 and promoted to Associate Professor in 2010. She is Co-director – with Professor Paul J Thornalley - of the Protein Damage and Systems Biology Research Group, Warwick Medical School. She employs “gold standard” stable isotopic dilution analysis mass spectrometry for comprehensive and quantitatively screening of amino acids and related glycated, oxidised and nitrated derivatives in mammalian cell culture, pre-clinical animal pharmacology and clinical studies – including working with several national and international collaborating research groups.
Her current research focuses on investigations of damage to lipoproteins and influence of dietary bioactive compounds on lipoprotein synthesis, damage and metabolism - supported by the BHF and BBSRC.
(i) Study co-ordinator of a pilot-scale placebo-controlled, double blind clinical trial of high dose thiamine therapy in type 2 diabetic patients with microalbuminuria in Shaikh Zayed Hospital, Lahore, Pakistan. The outcome - published recently – showed reversal of early stage kidney disease and improvement of kidney function of all patients receiving thiamine.
(ii) She is Editor of IMARS Highlights – the bimonthly newsletter of the International Maillard Reaction Society (IMARS).
(iii) Founding co-editor of the glycation section of the journal Amino Acid (first issue published by the end of 2010) - Text
Protein Damage and Systems Biology are a multi-disciplinary group, working in the field of disease mechanisms - particularly in the study of damage to the proteome by glycation, oxidation and nitration, related enzymatic countermeasures and other metabolic dysfunctions. Diseases under current investigation are: vascular complications of diabetes, renal failure and ageing. Therapeutic problems under current investigation are: high dose thiamine therapy for the prevention of diabetic nephropathy, dialysis renal replacement therapy, multi-drug resistance in cancer chemotherapy, and cancer chemoprevention
International Maillard Reaction Society (Editor of IMARS Highlights Newsletter)
Take a look at current research projects
Take a look at selected publications
- Karachalias, N., Babaei-Jadidi, R., Rabbani, N. and Thornalley, P.J. (2010) Protein glycation, oxidation and nitration in renal glomeruli, retina, nerve, plasma and urine of streptozotocin-induced diabetic rats and effect of thiamine and Benfotiamine therapy. Diabetologia 53, 1506-1516.
- Rabbani, N., Varma Chittari, M., Bodmer C.W., Zehnder, D., Ceriello, A. and Thornalley P.J. (2010) Increased glycation and oxidative damage to apolipoprotein B100 of LDL in patients with type 2 diabetes and effect of thiamine and Benfotiamine therapy. Diabetes 59, 1038-1045.
- Thornalley, P.J., Waris, S., Fleming, T., Santarius, T., Larkin, S.J., Winklhofer-Roob, B.M., Stratton, M.R. and Rabbani, N. (2010) Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance. Nucleic Acids Reseasrch, in press.
- Thornalley, P.J., Xue, M. and Rabbani, N. (2010) Methodologies for in-vitro and in-vivo activity of bioactive compounds. In: Health-Promoting Properties of Fruits and Vegetables (Terry, L. ed.), CABI, Oxford, UK., in press.
- Thornalley, P.J., Xue, M. and Rabbani, N. (2010) Thiamine in diabetic and renal disease - dietary insufficiency, renal washout, anti-stress gene response, therapeutic supplements, risk predictor and link to genetic susceptibility. In: 'Oxidative Stress in Applied BGasic Research and Clinical Practice: Renal Disorders', Springer, in press.
- Thornalley, P.J., Xue, M. and Rabbani N. (2010) Oxidation modification of proteins: an overview. In: Biomarkers For Antioxidant Defense And Oxidative Damange Principles And Practical Applications (ldini, G., Yeum, K-J., Niki, E. and Russell, R.M. eds), Wiley-Blackwell, New York, in press.
- Rabbani, N. and Thornalley, P.J. (2010) Dicarbonyls in cola drinks sweetened with sucrose or high fructose corn syrup. The Maillard Reaction: Interface Between Aging, Nutrition and Metabolism (Thomas, M. and Forbes, J. eds), J. Chem. Soc. (London) Special Periodical Report, in press.
- Kurz, A., Rabbani, N., Walter, M., Bonin, M., Thornalley, P.J., Auburger, G. and Gispert, S. (2010) Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress. Cell and Molecular Life Sci., in press.
|10/2001 to 12/2002||Postdoctoral Research Officer, Disease Mechanisms & Therapeutics Research Group Department of Biological Sciences, University of Essex, Colchester.
Project: "Evaluation of methylglyoxal derived protein glycation adducts as medium term indicators of postprandial & fasting hyperclycaemia in type 1 clinical diabetes mellitus" (Juvenile Diabetes Reserach Funded)
|01/2003 to 12/2005||Senior Research Officer, Disease Mechanisms & Therapeutics Research Group Department of Biological Sciences, University of Essex, Colchester.
Project: "Glycation of human serum albumin, haemoglobin & lens crystallins & capsule collagen by methylglyoxal & other α-oxoaldehydes in vivo: site, extent & structural & functional consequences of modification" (Wellcome Trust Funded)
|01/2006 to 12/2008||
British Heart Foundation Intermediate Research Fellow, Protein Damage & Systems Biology Research Group Clinical Sciences Research Institute, Warwick Medical School, Coventry.
Project: Glycation of lipoproteins in type 2 diabetes & atherogenicity.
Membership to professional associations
Diabetes UK, London, UK
American Diabetes Association (ADA), Alexandria, USA
European Association For the Study of Diabetes (EASD), Dusseldorf, Germany
Biochemical Society, London, UK